The BH3‐mimetic ABT‐737 inhibits allogeneic immune responses

Summary Apoptosis controls the adaptive immune system through regulation of central and peripheral lymphocyte deletion. Therefore, substances that selectively interact with the intrinsic apoptosis pathway in lymphocytes offer unexplored opportunities to pharmacologically modulate the immune response...

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Veröffentlicht in:	Transplant international 2011-07, Vol.24 (7), p.722-732
Hauptverfasser:	Cippà, Pietro E., Kraus, Anna K., Edenhofer, Ilka, Segerer, Stephan, Chen, Jin, Hausmann, Martin, Liu, Yang, Guimezanes, Annick, Bardwell, Philip D., Wüthrich, Rudolf P., Fehr, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	ABT‐737 allograft Animals Apoptosis Apoptosis - drug effects B-Lymphocytes - drug effects B-Lymphocytes - immunology Bcl-2 protein Bcl‐2 Biphenyl Compounds - pharmacology Cell activation Cell proliferation Cyclosporine - pharmacology Cyclosporins Cytotoxicity Graft rejection Graft Rejection - drug therapy Graft Rejection - prevention & control Immune response Immunosuppression Immunosuppressive Agents - pharmacology Inflammation Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lymphocytes B Lymphocytes T Lymphoid cells Major histocompatibility complex Mice Nitrophenols - pharmacology Piperazines - pharmacology Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors Skin Skin & tissue grafts Skin Transplantation - immunology Sulfonamides - pharmacology T cell receptors T-Lymphocytes - drug effects T-Lymphocytes - immunology transplantation Transplants & implants
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