Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception

Abstract Nucleotide-activated P2X channels and P2Y metabotropic receptors participate in nociceptive signaling. Agonist availability is regulated by nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), -2, -3, and -8, a family of enzymes that hydrolyze extracellular ATP to generate ADP (a P2Y ag...

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Veröffentlicht in:	Neuroscience 2011-10, Vol.193, p.387-398
Hauptverfasser:	Vongtau, H.O, Lavoie, E.G, Sévigny, J, Molliver, D.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Nucleotides - metabolism Adenosine Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Adenosinetriphosphatase AMP analgesic Animals ATP Axons CD39 antigen Circuits Corpuscles Disease Models, Animal Dorsal horn Dorsal root ganglia Dorsal roots ecto-nucleotidases Enzymes Ethanol - analogs & derivatives Ethanol - pharmacology Follicles Ganglia, Spinal - pathology Gene Expression Regulation - physiology Glycoproteins - metabolism Histochemistry Immunohistochemistry Male Metabotropic receptors Mice Mice, Inbred C57BL mRNA Neurology Neurons Neurotransmission Nociception - drug effects Nociception - physiology Nociceptors nucleoside triphosphates Nucleotidase Nucleotides P2Y receptors pain Pain perception Purine P2X receptors Purine P2Y receptors Pyrophosphatases - genetics Pyrophosphatases - metabolism Schwann cells Sensory neurons Sensory Receptor Cells - drug effects Signal transduction Skin - metabolism Spinal cord Spinal Cord - pathology TRPV Cation Channels - metabolism
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