Prevalence of Multidrug and Extensively Drug-Resistant Tuberculosis in Beijing, China: a Hospital-Based Retrospective Study
Tuberculosis (TB) is a disease of worldwide public-health concern. The development of resistance to an increasing number of second-line drugs and those used to treat multidrug-resistant (MDR) TB is rapidly becoming an emergency that could hinder the prevention and treatment of TB globally. This stud...
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| Veröffentlicht in: | Japanese Journal of Infectious Diseases 2010/09/30, Vol.63(5), pp.368-371 |
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| container_title | Japanese Journal of Infectious Diseases |
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| creator | Wang, Di Yang, Caie Kuang, Tieji Lei, Hong Meng, Xianghong Tong, Aihua He, Jufang Jiang, Ying Guo, Fengjie Dong, Mei |
| description | Tuberculosis (TB) is a disease of worldwide public-health concern. The development of resistance to an increasing number of second-line drugs and those used to treat multidrug-resistant (MDR) TB is rapidly becoming an emergency that could hinder the prevention and treatment of TB globally. This study describes the resistance profile of MDR and extensively drug-resistant (XDR) TB with a hospital-based survey in Beijing, China, conducted in the period 2007 to 2009. Drug-susceptibility tests performed on 967 Mycobacterium tuberculosis strains isolated from 967 patients showed that the rate of resistance to at least one first-line and at least one second-line drug was 70.1% and 60.7%, respectively. The overall MDR rate was 19.4%, and 14.9% of the MDR cases were XDR. In conclusion, MDR and XDR TB represent a significant number of total TB cases, therefore effective measures to manage these resistant strains are desperately needed. Development of a national TB policy in China might be a key method for solving the present problems of TB management. |
| doi_str_mv | 10.7883/yoken.63.368 |
| format | Article |
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The development of resistance to an increasing number of second-line drugs and those used to treat multidrug-resistant (MDR) TB is rapidly becoming an emergency that could hinder the prevention and treatment of TB globally. This study describes the resistance profile of MDR and extensively drug-resistant (XDR) TB with a hospital-based survey in Beijing, China, conducted in the period 2007 to 2009. Drug-susceptibility tests performed on 967 Mycobacterium tuberculosis strains isolated from 967 patients showed that the rate of resistance to at least one first-line and at least one second-line drug was 70.1% and 60.7%, respectively. The overall MDR rate was 19.4%, and 14.9% of the MDR cases were XDR. In conclusion, MDR and XDR TB represent a significant number of total TB cases, therefore effective measures to manage these resistant strains are desperately needed. Development of a national TB policy in China might be a key method for solving the present problems of TB management.</description><identifier>ISSN: 1344-6304</identifier><identifier>EISSN: 1884-2836</identifier><identifier>DOI: 10.7883/yoken.63.368</identifier><identifier>PMID: 20859008</identifier><language>eng</language><publisher>Japan: National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</publisher><subject>Antitubercular Agents - pharmacology ; China - epidemiology ; Extensively Drug-Resistant Tuberculosis - epidemiology ; Extensively Drug-Resistant Tuberculosis - microbiology ; Female ; Humans ; Male ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - drug effects ; Prevalence ; Retrospective Studies</subject><ispartof>Japanese Journal of Infectious Diseases, 2010/09/30, Vol.63(5), pp.368-371</ispartof><rights>2010 Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-548b2cb37b264b132d724ddd02c97e0bcb9e47e30da8404901f4b7cbfe2cbc8a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20859008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Di</creatorcontrib><creatorcontrib>Yang, Caie</creatorcontrib><creatorcontrib>Kuang, Tieji</creatorcontrib><creatorcontrib>Lei, Hong</creatorcontrib><creatorcontrib>Meng, Xianghong</creatorcontrib><creatorcontrib>Tong, Aihua</creatorcontrib><creatorcontrib>He, Jufang</creatorcontrib><creatorcontrib>Jiang, Ying</creatorcontrib><creatorcontrib>Guo, Fengjie</creatorcontrib><creatorcontrib>Dong, Mei</creatorcontrib><title>Prevalence of Multidrug and Extensively Drug-Resistant Tuberculosis in Beijing, China: a Hospital-Based Retrospective Study</title><title>Japanese Journal of Infectious Diseases</title><addtitle>Jpn J Infect Dis</addtitle><description>Tuberculosis (TB) is a disease of worldwide public-health concern. The development of resistance to an increasing number of second-line drugs and those used to treat multidrug-resistant (MDR) TB is rapidly becoming an emergency that could hinder the prevention and treatment of TB globally. This study describes the resistance profile of MDR and extensively drug-resistant (XDR) TB with a hospital-based survey in Beijing, China, conducted in the period 2007 to 2009. Drug-susceptibility tests performed on 967 Mycobacterium tuberculosis strains isolated from 967 patients showed that the rate of resistance to at least one first-line and at least one second-line drug was 70.1% and 60.7%, respectively. The overall MDR rate was 19.4%, and 14.9% of the MDR cases were XDR. In conclusion, MDR and XDR TB represent a significant number of total TB cases, therefore effective measures to manage these resistant strains are desperately needed. Development of a national TB policy in China might be a key method for solving the present problems of TB management.</description><subject>Antitubercular Agents - pharmacology</subject><subject>China - epidemiology</subject><subject>Extensively Drug-Resistant Tuberculosis - epidemiology</subject><subject>Extensively Drug-Resistant Tuberculosis - microbiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><issn>1344-6304</issn><issn>1884-2836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9vFCEYhifGxtbqzbPh5qWzMsAMjDd3ra1JG02tZ8KPb7asLLMFpnHjP1_qtuuxFyAvD0_C91bVuwbPuBD043b8DWHW0RntxIvqqBGC1UTQ7mU5U8bqjmJ2WL1OaYUxadsGv6oOCRZtj7E4qv7-iHCnPAQDaBzQ5eSzs3FaIhUsOv2TISR3B36LvpSwvoLkUlYho-tJQzSTH0uAXEBzcCsXlidoceOC-oQUOh_TxmXl67lKYNEV5FgSMLn40M882e2b6mBQPsHbx_24-vX19HpxXl98P_u2-HxRm7YnuW6Z0MRoyjXpmG4osZwway0mpueAtdE9MA4UWyUYZj1uBqa50QOUV0Yoelx92Hk3cbydIGW5dsmA9yrAOCXZY95w3OLmWZKX-fUCU1bIkx1pyq9ShEFuoluruJUNlg-9yH-9yI7K0kvB3z-KJ70Gu4efiijAfAesynyXsAdUzM54-G9rH5addX9pblSUEOg9seGj4Q</recordid><startdate>20100930</startdate><enddate>20100930</enddate><creator>Wang, Di</creator><creator>Yang, Caie</creator><creator>Kuang, Tieji</creator><creator>Lei, Hong</creator><creator>Meng, Xianghong</creator><creator>Tong, Aihua</creator><creator>He, Jufang</creator><creator>Jiang, Ying</creator><creator>Guo, Fengjie</creator><creator>Dong, Mei</creator><general>National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20100930</creationdate><title>Prevalence of Multidrug and Extensively Drug-Resistant Tuberculosis in Beijing, China: a Hospital-Based Retrospective Study</title><author>Wang, Di ; Yang, Caie ; Kuang, Tieji ; Lei, Hong ; Meng, Xianghong ; Tong, Aihua ; He, Jufang ; Jiang, Ying ; Guo, Fengjie ; Dong, Mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-548b2cb37b264b132d724ddd02c97e0bcb9e47e30da8404901f4b7cbfe2cbc8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antitubercular Agents - pharmacology</topic><topic>China - epidemiology</topic><topic>Extensively Drug-Resistant Tuberculosis - epidemiology</topic><topic>Extensively Drug-Resistant Tuberculosis - microbiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Di</creatorcontrib><creatorcontrib>Yang, Caie</creatorcontrib><creatorcontrib>Kuang, Tieji</creatorcontrib><creatorcontrib>Lei, Hong</creatorcontrib><creatorcontrib>Meng, Xianghong</creatorcontrib><creatorcontrib>Tong, Aihua</creatorcontrib><creatorcontrib>He, Jufang</creatorcontrib><creatorcontrib>Jiang, Ying</creatorcontrib><creatorcontrib>Guo, Fengjie</creatorcontrib><creatorcontrib>Dong, Mei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Japanese Journal of Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Di</au><au>Yang, Caie</au><au>Kuang, Tieji</au><au>Lei, Hong</au><au>Meng, Xianghong</au><au>Tong, Aihua</au><au>He, Jufang</au><au>Jiang, Ying</au><au>Guo, Fengjie</au><au>Dong, Mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of Multidrug and Extensively Drug-Resistant Tuberculosis in Beijing, China: a Hospital-Based Retrospective Study</atitle><jtitle>Japanese Journal of Infectious Diseases</jtitle><addtitle>Jpn J Infect Dis</addtitle><date>2010-09-30</date><risdate>2010</risdate><volume>63</volume><issue>5</issue><spage>368</spage><epage>371</epage><pages>368-371</pages><artnum>63.368</artnum><issn>1344-6304</issn><eissn>1884-2836</eissn><abstract>Tuberculosis (TB) is a disease of worldwide public-health concern. The development of resistance to an increasing number of second-line drugs and those used to treat multidrug-resistant (MDR) TB is rapidly becoming an emergency that could hinder the prevention and treatment of TB globally. This study describes the resistance profile of MDR and extensively drug-resistant (XDR) TB with a hospital-based survey in Beijing, China, conducted in the period 2007 to 2009. Drug-susceptibility tests performed on 967 Mycobacterium tuberculosis strains isolated from 967 patients showed that the rate of resistance to at least one first-line and at least one second-line drug was 70.1% and 60.7%, respectively. The overall MDR rate was 19.4%, and 14.9% of the MDR cases were XDR. In conclusion, MDR and XDR TB represent a significant number of total TB cases, therefore effective measures to manage these resistant strains are desperately needed. 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| subjects | Antitubercular Agents - pharmacology China - epidemiology Extensively Drug-Resistant Tuberculosis - epidemiology Extensively Drug-Resistant Tuberculosis - microbiology Female Humans Male Microbial Sensitivity Tests Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Prevalence Retrospective Studies |
| title | Prevalence of Multidrug and Extensively Drug-Resistant Tuberculosis in Beijing, China: a Hospital-Based Retrospective Study |
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