DNA Repair Gene and MTHFR Gene Polymorphisms as Prognostic Markers in Locally Advanced Adenocarcinoma of the Esophagus or Stomach Treated with Cisplatin and 5-Fluorouracil-Based Neoadjuvant Chemotherapy

Background DNA repair plays an important role in chemoresistance to platinum-based therapy, and therefore polymorphisms in the genes may modulate therapeutic response. We assessed 12 polymorphisms in 7 DNA repair genes and 2 polymorphisms in the MTHFR gene for association with disease response and p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of surgical oncology 2011-09, Vol.18 (9), p.2688-2698
Hauptverfasser:	Ott, Katja, Rachakonda, P. Sivaramakrishna, Panzram, Benjamin, Keller, Gisela, Lordick, Florian, Becker, Karen, Langer, Rupert, Buechler, Markus, Hemminki, Kari, Kumar, Rajiv
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - secondary Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cisplatin - administration & dosage Clinical Trials, Phase II as Topic DNA Repair - genetics DNA, Neoplasm - genetics Esophageal Neoplasms - drug therapy Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Female Fluorouracil - administration & dosage Follow-Up Studies Genotype Humans Male Medicine Medicine & Public Health Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged Neoadjuvant Therapy Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Neoplasm Staging Oncology Polymerase Chain Reaction Polymorphism, Genetic - genetics Prospective Studies Retrospective Studies Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - pathology Surgery Surgical Oncology Survival Rate Translational Research and Biomarkers Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!