Pdcd4 tumor suppressor: Properties, functions, and possible applications in oncology
The inactivation of tumor suppressors and activation of protooncogenes are critical events in malignant cell transformation and tumor progression. Pdcd4 encodes a protein with tumor suppressor functions, which accounts for the increased interest in Pdcd4 as a potential diagnostic and prognostic mark...
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| Veröffentlicht in: | Molecular genetics, microbiology and virology microbiology and virology, 2010-06, Vol.25 (2), p.47-55 |
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| container_title | Molecular genetics, microbiology and virology |
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| creator | Vikhreva, P. N Shepelev, M. V Korobko, E. V Korobko, I. V |
| description | The inactivation of tumor suppressors and activation of protooncogenes are critical events in malignant cell transformation and tumor progression. Pdcd4 encodes a protein with tumor suppressor functions, which accounts for the increased interest in Pdcd4 as a potential diagnostic and prognostic marker and a target for anti-neoplastic therapy. The review summarizes the well-known properties and functions of Pdcd4 tumor suppressor and the mechanisms of its regulation in tumor tissues, the role of Pdcd4 in cellular transformation and tumor progression, and its potential practical application in oncology. |
| doi_str_mv | 10.3103/S0891416810020011 |
| format | Article |
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| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Biomedical and Life Sciences cancer gene therapy Cancer Proteomics Life Sciences Microbiology molecular marker Molecular Medicine Pdcd4 regulation of expression tumor suppressor |
| title | Pdcd4 tumor suppressor: Properties, functions, and possible applications in oncology |
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