Advanced glycation end-products induce heparanase expression in endothelial cells by the receptor for advanced glycation end products and through activation of the FOXO4 transcription factor

As an endo-β (1-4)- d -glucuronidase, heparanase can specifically cleave carbohydrate chains of heparan sulfate (HS) and has been implicated in development of endothelial cells dsyfunction. The advanced glycation end products (AGEs) play a pivotal role in the pathology of diabetic complications. In...

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Veröffentlicht in:	Molecular and cellular biochemistry 2011-08, Vol.354 (1-2), p.47-55
Hauptverfasser:	An, Xiao-Fei, Zhou, Lei, Jiang, Peng-Jun, Yan, Ming, Huang, Yu-Jun, Zhang, Su-Na, Niu, Yun-Fei, Ten, Shi-Chao, Yu, Jiang-Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological products Biomedical and Life Sciences Cardiology Cattle Cells Diabetic Nephropathies - metabolism Endothelial Cells - metabolism Endothelium Endothelium, Vascular - cytology Gene expression Glucuronidase - genetics Glucuronidase - metabolism Glycation End Products, Advanced - metabolism Glycation End Products, Advanced - pharmacology Glycosylation Humans L-Lactate Dehydrogenase - metabolism Life Sciences Medical Biochemistry Microvessels - cytology Neurons Neutralization NF-kappa B - genetics NF-kappa B - metabolism Oncology Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Receptor for Advanced Glycation End Products Receptors, Immunologic - metabolism RNA Serum Albumin, Bovine - metabolism Serum Albumin, Bovine - pharmacology Sulfates Transcription Factors - metabolism Transcription, Genetic
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