BBR induces apoptosis in HepG2 cell through an Akt-ASK1-ROS-p38MAPKs-linked cascade

Berberine (BBR) has indicated significant antimicrobial activity against a variety of organisms including bacteria, viruses, and fungi. The mechanism by which BBR initiates apoptosis remains poorly understood. In the present study, we demonstrated that BBR exhibited significant cytotoxicity in human...

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Veröffentlicht in:	Journal of cellular biochemistry 2010-02, Vol.109 (2), p.329-338
Hauptverfasser:	Hyun, Mee-Sun, Hur, Jung-Mu, Mun, Yeun-Ja, Kim, Dongho, Woo, Won-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Annexin A5 - metabolism apoptosis Apoptosis - drug effects ASK1 bcl-2-Associated X Protein - metabolism berberine Berberine - pharmacology Caspase 3 - metabolism DNA Fragmentation - drug effects Hep G2 Cells Humans JNK Mitogen-Activated Protein Kinases - metabolism MAP Kinase Kinase Kinase 5 - metabolism p38 p38 Mitogen-Activated Protein Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive Oxygen Species - metabolism ROS Signal Transduction - drug effects Signal Transduction - physiology Tumor Suppressor Protein p53 - metabolism
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