Refractory Evans Syndrome after Autologous Stem Cell Transplantation for Multiple Myeloma: Management with a Second Transplantation
The development of autoimmune disease after autologous stem cell transplantation (ASCT) is very rare in multiple myeloma (MM). We describe the first case of Evans syndrome after ASCT for MM. A 60-year-old man with MM received ASCT and subsequently developed Evans syndrome following two febrile episo...
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| Veröffentlicht in: | Internal Medicine 2010, Vol.49(7), pp.683-687 |
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| container_title | Internal Medicine |
| container_volume | 49 |
| creator | Chihara, Dai Sakamoto, Takashi Arimoto-Miyamoto, Kazue Kishimoto, Wataru Takeoka, Tomoharu Tsuji, Masaaki Ohno, Tatsuharu |
| description | The development of autoimmune disease after autologous stem cell transplantation (ASCT) is very rare in multiple myeloma (MM). We describe the first case of Evans syndrome after ASCT for MM. A 60-year-old man with MM received ASCT and subsequently developed Evans syndrome following two febrile episodes. The syndrome was refractory to conventional therapies but it was managed with a second ASCT. This unique complication was thought to have been triggered by an infection during the recovery of the immune system. We assumed that reconstructing the immune system via ASCT might eliminate infection-induced autoantibodies to platelets and erythrocytes. |
| doi_str_mv | 10.2169/internalmedicine.49.2922 |
| format | Article |
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Med.</addtitle><description>The development of autoimmune disease after autologous stem cell transplantation (ASCT) is very rare in multiple myeloma (MM). We describe the first case of Evans syndrome after ASCT for MM. A 60-year-old man with MM received ASCT and subsequently developed Evans syndrome following two febrile episodes. The syndrome was refractory to conventional therapies but it was managed with a second ASCT. This unique complication was thought to have been triggered by an infection during the recovery of the immune system. 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Med.</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>49</volume><issue>7</issue><spage>683</spage><epage>687</epage><pages>683-687</pages><issn>0918-2918</issn><issn>1349-7235</issn><eissn>1349-7235</eissn><abstract>The development of autoimmune disease after autologous stem cell transplantation (ASCT) is very rare in multiple myeloma (MM). We describe the first case of Evans syndrome after ASCT for MM. A 60-year-old man with MM received ASCT and subsequently developed Evans syndrome following two febrile episodes. The syndrome was refractory to conventional therapies but it was managed with a second ASCT. This unique complication was thought to have been triggered by an infection during the recovery of the immune system. 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| fulltext | fulltext |
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| ispartof | Internal Medicine, 2010, Vol.49(7), pp.683-687 |
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| language | eng |
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| subjects | Autoimmune Diseases - diagnosis Autoimmune Diseases - etiology Autoimmune Diseases - surgery autologous stem cell transplantation Disease Management Evans syndrome Fatal Outcome Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Humans Male Middle Aged multiple myeloma Multiple Myeloma - pathology Multiple Myeloma - surgery Syndrome Transplantation Conditioning Transplantation, Autologous |
| title | Refractory Evans Syndrome after Autologous Stem Cell Transplantation for Multiple Myeloma: Management with a Second Transplantation |
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