Down-regulation of Expression of Interleukin-6 and its Receptor Results in Growth Inhibition of MCF-7 Breast Cancer Cells

Interleukin-6 (IL-6) plays an important role in the neoplastic process through its action on cancer cell adhesion, motility, proliferation, tumor-specific antigen expression, and thrombopoiesis. IL-6 exerts its activity by binding to a high affinity receptor complex consisting of two membrane glycop...

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Veröffentlicht in:	Anticancer research 2011-09, Vol.31 (9), p.2899-2906
Hauptverfasser:	JIANG, Xian-Peng, DING CHENG YANG, ELLIOTT, Robert L, HEAD, Jonathan F
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor DNA Primers Down-Regulation Electrophoresis, Agar Gel Enzyme-Linked Immunosorbent Assay Female Gynecology. Andrology. Obstetrics Humans Interleukin-6 - metabolism Mammary gland diseases Medical sciences Receptors, Interleukin-6 - metabolism Reverse Transcriptase Polymerase Chain Reaction Tumors
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