Induction of antitumor immunity using dendritic cells electroporated with Polo‐like kinase 1 (Plk1) mRNA in murine tumor models

Polo‐like kinase 1 (Plk1), a serine–threonine kinase, plays a key role in the regulation of the cell cycle. Elevated Plk1 expression in various cancers is correlated with poor prognosis and poor patient survival rates. Several Plk1 inhibitors are currently being developed as potential treatments for...

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Veröffentlicht in:	Cancer science 2011-08, Vol.102 (8), p.1448-1454
Hauptverfasser:	Park, Jung‐Sun, Sohn, Hyun‐Jung, Park, Gyeong‐Sin, Chung, Yeun‐Jun, Kim, Tai‐Gyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antigen (tumor-associated) Antitumor activity Biological and medical sciences Cancer CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen Cell cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - immunology Cell Line, Tumor Cytotoxicity Dendritic cells Dendritic Cells - immunology Electroporation Female Humans Immunotherapy Lymphocytes T Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Monocytes mRNA Neoplasms, Experimental - immunology Neoplasms, Experimental - therapy Peripheral blood mononuclear cells plk1 protein Polo-Like Kinase 1 Prognosis Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - immunology Protein-serine/threonine kinase Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - immunology RNA, Messenger - genetics T-Lymphocytes, Cytotoxic - immunology Tumor cell lines Tumors Vaccination
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