The Proapoptotic Function of Noxa in Human Leukemia Cells Is Regulated by the Kinase Cdk5 and by Glucose

The BH3-only protein, Noxa, is induced in response to apoptotic stimuli, such as DNA damage, hypoxia, and proteasome inhibition in most human cells. Noxa is constitutively expressed in proliferating cells of hematopoietic lineage and required for apoptosis in response to glucose stress. We show that...

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Veröffentlicht in:	Molecular cell 2010-12, Vol.40 (5), p.823-833
Hauptverfasser:	Lowman, Xazmin H., McDonnell, Maureen A., Kosloske, Ashley, Odumade, Oludare A., Jenness, Christopher, Karim, Christine B., Jemmerson, Ronald, Kelekar, Ameeta
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Cell Line, Tumor Cyclin-Dependent Kinase 5 - genetics Cyclin-Dependent Kinase 5 - metabolism Glucose - metabolism Humans Leukemia - enzymology Leukemia - metabolism Phosphorylation Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism
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