The Skp2 Promoter Integrates Signaling through the NF- Kappa B, p53, and Akt/GSK3 beta Pathways to Regulate Autophagy and Apoptosis

NF- Kappa B and p53 are important regulators of the cellular response to stress. Here, we identify the Skp2 gene as being both an NF- Kappa B and p53 target after DNA damage. However, Skp2 expression can be either induced or repressed in a manner requiring both the p52 NF- Kappa B subunit and p53, w...

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Veröffentlicht in:	Molecular cell 2010-05, Vol.38 (4), p.524-538
Hauptverfasser:	Barre, Benjamin, Perkins, Neil D
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein
Online-Zugang:	Volltext
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