Persistent CMV infection correlates with disease activity and dominates the phenotype of peripheral CD8+ T cells in psoriasis

: Background: Previously, we have reported a frequent association of active plaque psoriasis with inflammation‐mediated cytomegalovirus (CMV) reactivation. Objectives: This study aimed at characterizing the impact of CMV infection on psoriasis disease activity and peripheral cellular adaptive immu...

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Veröffentlicht in:	Experimental dermatology 2011-07, Vol.20 (7), p.561-567
Hauptverfasser:	Weitz, Mario, Kiessling, Corinna, Friedrich, Markus, Prösch, Susanna, Höflich, Conny, Kern, Florian, Volk, Hans-Dieter, Sterry, Wolfram, Asadullah, Khusru, Döcke, Wolf-Dietrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, CD - metabolism Antigens, Differentiation, T-Lymphocyte - metabolism Antigens, Viral - metabolism Biological and medical sciences CD11a antigen CD11a Antigen - metabolism CD28 Antigens - metabolism CD57 Antigens - metabolism CD8 antigen CD8+ T cells CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology CMV CTLA-4 Antigen - metabolism Cytomegalovirus Cytomegalovirus Infections - complications Cytomegalovirus Infections - diagnosis Cytomegalovirus Infections - epidemiology Cytomegalovirus Infections - immunology Data processing Dermatology Differentiation disease activity Female HLA-DR Antigens - metabolism Humans Immunoglobulin G - blood Immunoglobulin G - immunology immunophenotype Immunophenotyping Infection Infectious diseases Interleukin-2 Receptor alpha Subunit - metabolism L-Selectin - metabolism Leukocyte Common Antigens - metabolism Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - virology Lymphocyte Count Lymphocytes T Male Medical sciences Membrane Glycoproteins - metabolism Middle Aged Plaques Psoriasis Psoriasis - complications Psoriasis - diagnosis Psoriasis - epidemiology Psoriasis - immunology Psoriasis - therapy Psoriasis - virology Psoriasis. Parapsoriasis. Lichen Receptors, Transferrin - metabolism Seroepidemiologic Studies Severity of Illness Index T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism Viral diseases
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