Heat-shock induction of tumor-derived danger signals mediates rapid monocyte differentiation into clinically effective dendritic cells

This study characterizes, biologically and clinically, a novel type of dendritic cells (DC) produced in the short term and called tumor antigen-presenting cells (TAPCells). In particular, we identified factors present in a lysate derived from heat-shocked allogeneic melanoma cells (TRIMEL) that are...

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Veröffentlicht in:	Clinical cancer research 2011-04, Vol.17 (8), p.2474-2483
Hauptverfasser:	Aguilera, Raquel, Saffie, Carlos, Tittarelli, Andrés, González, Fermín E, Ramírez, Marcos, Reyes, Diego, Pereda, Cristián, Hevia, Daniel, García, Tamara, Salazar, Lorena, Ferreira, Arturo, Hermoso, Marcela, Mendoza-Naranjo, Ariadna, Ferrada, Carlos, Garrido, Paola, López, Mercedes N, Salazar-Onfray, Flavio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism Antigens, Neoplasm - immunology Calreticulin - immunology Calreticulin - metabolism Cancer Vaccines - immunology Cancer Vaccines - therapeutic use Cell Differentiation - immunology Cell Line, Tumor Dendritic Cells - immunology Dendritic Cells - metabolism Female Flow Cytometry HMGB1 Protein - immunology HMGB1 Protein - metabolism Hot Temperature Humans Hypersensitivity, Delayed - immunology Immunophenotyping K562 Cells Kaplan-Meier Estimate Male Melanoma - drug therapy Melanoma - immunology Middle Aged Monocytes - immunology Monocytes - metabolism Signal Transduction - immunology T-Lymphocytes - immunology T-Lymphocytes - metabolism Young Adult
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