c-Jun amplification and overexpression are oncogenic in liposarcoma but not always sufficient to inhibit the adipocytic differentiation programme

Genomic amplification of c-Jun and its upstream kinases have been implicated as a mechanism of progression from well-differentiated to dedifferentiated liposarcoma. To further define the role of c-Jun in liposarcoma progression, we performed immunohistochemistry for c-Jun and its activating kinase A...

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Veröffentlicht in:	The Journal of pathology 2009-07, Vol.218 (3), p.292-300
Hauptverfasser:	Snyder, Eric L, Sandstrom, Deborah J, Law, Kenneth, Fiore, Christopher, Sicinska, Ewa, Brito, Joseph, Bailey, Dyane, Fletcher, Jonathan A, Loda, Massimo, Rodig, Scott J, Dal Cin, Paola, Fletcher, Christopher DM
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - pathology Animals Biological and medical sciences c-Jun c-Jun protein Cell Differentiation - physiology Cell Line, Tumor Cell number Chromosomes dedifferentiation Dermatology Differentiation Disease Progression Evolution Fluorescence in situ hybridization Gene Amplification Genes, jun genomics Humans Immunohistochemistry In Situ Hybridization, Fluorescence Investigative techniques, diagnostic techniques (general aspects) Liposarcoma Liposarcoma - genetics Liposarcoma - metabolism Liposarcoma - pathology MAP kinase MAP Kinase Kinase Kinase 5 - metabolism MDM2 protein Medical sciences Mice Mice, Nude Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proto-Oncogene Proteins c-jun - metabolism Transcription factors Tumors of the skin and soft tissue. Premalignant lesions
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