Autoimmune Pancreatitis with Extreme Elevation of DUPAN-2
An 80-year-old woman was admitted to our hospital with complaints of jaundice and liver dysfunction. She was found to have a high titer of serum IgG4, positive rheumatoid factor and marked elevation of DUPAN-2 (11,148 U/ml). Computed tomography showed swelling of the pancreas, and endoscopic retrogr...
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| Veröffentlicht in: | Internal Medicine 2007, Vol.46(7), pp.377-381 |
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| container_title | Internal Medicine |
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| creator | Mishima, Shiho Mizuta, Yohei Yamao, Takuji Yamakawa, Masaki Akazawa, Yuko Mishima, Ryosuke Ohba, Kazuo Masuda, Jun-ich Ohnita, Ken Isomoto, Hajime Shikuwa, Saburo Omagari, Katsuhisa Kohno, Shigeru |
| description | An 80-year-old woman was admitted to our hospital with complaints of jaundice and liver dysfunction. She was found to have a high titer of serum IgG4, positive rheumatoid factor and marked elevation of DUPAN-2 (11,148 U/ml). Computed tomography showed swelling of the pancreas, and endoscopic retrograde cholangiopancreatography revealed diffuse irregular narrowing of the main pancreatic duct, which are typical findings of autoimmune pancreatitis. There was no evidence of malignancy. Administration of 30 mg/day of prednisolone was started. Computed tomography showed significant regression in the size of the pancreas, and the stenosis of the main pancreatic duct was improved on ERCP. The serum level of DUPAN-2 was also markedly decreased after the treatment. |
| doi_str_mv | 10.2169/internalmedicine.46.6184 |
| format | Article |
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She was found to have a high titer of serum IgG4, positive rheumatoid factor and marked elevation of DUPAN-2 (11,148 U/ml). Computed tomography showed swelling of the pancreas, and endoscopic retrograde cholangiopancreatography revealed diffuse irregular narrowing of the main pancreatic duct, which are typical findings of autoimmune pancreatitis. There was no evidence of malignancy. Administration of 30 mg/day of prednisolone was started. Computed tomography showed significant regression in the size of the pancreas, and the stenosis of the main pancreatic duct was improved on ERCP. The serum level of DUPAN-2 was also markedly decreased after the treatment.</description><identifier>ISSN: 0918-2918</identifier><identifier>ISSN: 1349-7235</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.46.6184</identifier><identifier>PMID: 17409601</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Acute Disease ; Adrenal Cortex Hormones - therapeutic use ; Aged, 80 and over ; Antigens, Neoplasm - blood ; Autoimmune Diseases - blood ; Autoimmune Diseases - diagnosis ; Autoimmune Diseases - drug therapy ; autoimmune pancreatitis ; Biomarkers - blood ; Cholangiopancreatography, Endoscopic Retrograde - methods ; Diagnosis, Differential ; DUPAN-2 ; Female ; Humans ; IgG4 ; Pancreatic Function Tests ; Pancreatic Neoplasms - diagnosis ; Pancreatitis - blood ; Pancreatitis - diagnosis ; Pancreatitis - drug therapy ; Risk Assessment ; Severity of Illness Index ; steroid ; Tomography, X-Ray Computed ; Treatment Outcome</subject><ispartof>Internal Medicine, 2007, Vol.46(7), pp.377-381</ispartof><rights>2007 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c598t-45ab6ffdbe6b0e0d275284b2c15f0cc1524b040754501bc09af5f03e6a9be5713</citedby><cites>FETCH-LOGICAL-c598t-45ab6ffdbe6b0e0d275284b2c15f0cc1524b040754501bc09af5f03e6a9be5713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17409601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mishima, Shiho</creatorcontrib><creatorcontrib>Mizuta, Yohei</creatorcontrib><creatorcontrib>Yamao, Takuji</creatorcontrib><creatorcontrib>Yamakawa, Masaki</creatorcontrib><creatorcontrib>Akazawa, Yuko</creatorcontrib><creatorcontrib>Mishima, Ryosuke</creatorcontrib><creatorcontrib>Ohba, Kazuo</creatorcontrib><creatorcontrib>Masuda, Jun-ich</creatorcontrib><creatorcontrib>Ohnita, Ken</creatorcontrib><creatorcontrib>Isomoto, Hajime</creatorcontrib><creatorcontrib>Shikuwa, Saburo</creatorcontrib><creatorcontrib>Omagari, Katsuhisa</creatorcontrib><creatorcontrib>Kohno, Shigeru</creatorcontrib><title>Autoimmune Pancreatitis with Extreme Elevation of DUPAN-2</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>An 80-year-old woman was admitted to our hospital with complaints of jaundice and liver dysfunction. She was found to have a high titer of serum IgG4, positive rheumatoid factor and marked elevation of DUPAN-2 (11,148 U/ml). Computed tomography showed swelling of the pancreas, and endoscopic retrograde cholangiopancreatography revealed diffuse irregular narrowing of the main pancreatic duct, which are typical findings of autoimmune pancreatitis. There was no evidence of malignancy. Administration of 30 mg/day of prednisolone was started. Computed tomography showed significant regression in the size of the pancreas, and the stenosis of the main pancreatic duct was improved on ERCP. The serum level of DUPAN-2 was also markedly decreased after the treatment.</description><subject>Acute Disease</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Aged, 80 and over</subject><subject>Antigens, Neoplasm - blood</subject><subject>Autoimmune Diseases - blood</subject><subject>Autoimmune Diseases - diagnosis</subject><subject>Autoimmune Diseases - drug therapy</subject><subject>autoimmune pancreatitis</subject><subject>Biomarkers - blood</subject><subject>Cholangiopancreatography, Endoscopic Retrograde - methods</subject><subject>Diagnosis, Differential</subject><subject>DUPAN-2</subject><subject>Female</subject><subject>Humans</subject><subject>IgG4</subject><subject>Pancreatic Function Tests</subject><subject>Pancreatic Neoplasms - diagnosis</subject><subject>Pancreatitis - blood</subject><subject>Pancreatitis - diagnosis</subject><subject>Pancreatitis - drug therapy</subject><subject>Risk Assessment</subject><subject>Severity of Illness Index</subject><subject>steroid</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><issn>0918-2918</issn><issn>1349-7235</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMotj7-gsxKV1OTTB6TZdH6gKJd6Dpk0js2Mg9NMj7-vSktCiJuzoV7vnsuHIQygieUCHXuugi-M00LS2ddBxMmJoKUbAeNScFULmnBd9EYK1LmNMkIHYTwjHFRSkX30YhIhpXAZIzUdIi9a9uhg2xhOuvBRBddyN5dXGWzj-ihhWzWwFva913W19nl42J6l9MjtFebJsDxdh6ix6vZw8VNPr-_vr2YznPLVRlzxk0l6npZgagw4CWVnJasopbwGtuklFWYYckZx6SyWJk6GQUIoyrgkhSH6GyT--L71wFC1K0LFprGdNAPQSssieBU4kSe_ksmhClJ1pHlBrS-D8FDrV-8a43_1ATrdcH6d8GaCb0uOJ2ebH8MVTJ_DreNJmC-AZ5DNE_wDRgfnW3gz2S5kULKb8yujNfQFV8n1Zen</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Mishima, Shiho</creator><creator>Mizuta, Yohei</creator><creator>Yamao, Takuji</creator><creator>Yamakawa, Masaki</creator><creator>Akazawa, Yuko</creator><creator>Mishima, Ryosuke</creator><creator>Ohba, Kazuo</creator><creator>Masuda, Jun-ich</creator><creator>Ohnita, Ken</creator><creator>Isomoto, Hajime</creator><creator>Shikuwa, Saburo</creator><creator>Omagari, Katsuhisa</creator><creator>Kohno, Shigeru</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20070101</creationdate><title>Autoimmune Pancreatitis with Extreme Elevation of DUPAN-2</title><author>Mishima, Shiho ; Mizuta, Yohei ; Yamao, Takuji ; Yamakawa, Masaki ; Akazawa, Yuko ; Mishima, Ryosuke ; Ohba, Kazuo ; Masuda, Jun-ich ; Ohnita, Ken ; Isomoto, Hajime ; Shikuwa, Saburo ; Omagari, Katsuhisa ; Kohno, Shigeru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c598t-45ab6ffdbe6b0e0d275284b2c15f0cc1524b040754501bc09af5f03e6a9be5713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acute Disease</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Aged, 80 and over</topic><topic>Antigens, Neoplasm - blood</topic><topic>Autoimmune Diseases - blood</topic><topic>Autoimmune Diseases - diagnosis</topic><topic>Autoimmune Diseases - drug therapy</topic><topic>autoimmune pancreatitis</topic><topic>Biomarkers - blood</topic><topic>Cholangiopancreatography, Endoscopic Retrograde - methods</topic><topic>Diagnosis, Differential</topic><topic>DUPAN-2</topic><topic>Female</topic><topic>Humans</topic><topic>IgG4</topic><topic>Pancreatic Function Tests</topic><topic>Pancreatic Neoplasms - diagnosis</topic><topic>Pancreatitis - blood</topic><topic>Pancreatitis - diagnosis</topic><topic>Pancreatitis - drug therapy</topic><topic>Risk Assessment</topic><topic>Severity of Illness Index</topic><topic>steroid</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mishima, Shiho</creatorcontrib><creatorcontrib>Mizuta, Yohei</creatorcontrib><creatorcontrib>Yamao, Takuji</creatorcontrib><creatorcontrib>Yamakawa, Masaki</creatorcontrib><creatorcontrib>Akazawa, Yuko</creatorcontrib><creatorcontrib>Mishima, Ryosuke</creatorcontrib><creatorcontrib>Ohba, Kazuo</creatorcontrib><creatorcontrib>Masuda, Jun-ich</creatorcontrib><creatorcontrib>Ohnita, Ken</creatorcontrib><creatorcontrib>Isomoto, Hajime</creatorcontrib><creatorcontrib>Shikuwa, Saburo</creatorcontrib><creatorcontrib>Omagari, Katsuhisa</creatorcontrib><creatorcontrib>Kohno, Shigeru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mishima, Shiho</au><au>Mizuta, Yohei</au><au>Yamao, Takuji</au><au>Yamakawa, Masaki</au><au>Akazawa, Yuko</au><au>Mishima, Ryosuke</au><au>Ohba, Kazuo</au><au>Masuda, Jun-ich</au><au>Ohnita, Ken</au><au>Isomoto, Hajime</au><au>Shikuwa, Saburo</au><au>Omagari, Katsuhisa</au><au>Kohno, Shigeru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autoimmune Pancreatitis with Extreme Elevation of DUPAN-2</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. 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| subjects | Acute Disease Adrenal Cortex Hormones - therapeutic use Aged, 80 and over Antigens, Neoplasm - blood Autoimmune Diseases - blood Autoimmune Diseases - diagnosis Autoimmune Diseases - drug therapy autoimmune pancreatitis Biomarkers - blood Cholangiopancreatography, Endoscopic Retrograde - methods Diagnosis, Differential DUPAN-2 Female Humans IgG4 Pancreatic Function Tests Pancreatic Neoplasms - diagnosis Pancreatitis - blood Pancreatitis - diagnosis Pancreatitis - drug therapy Risk Assessment Severity of Illness Index steroid Tomography, X-Ray Computed Treatment Outcome |
| title | Autoimmune Pancreatitis with Extreme Elevation of DUPAN-2 |
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