Transgenic expression of murine chemokine decoy receptor D6 by islets reveals the role of inflammatory CC chemokines in the development of autoimmune diabetes in NOD mice

Aims/hypothesis Autoimmune diabetes results from a progressive destruction of insulin-producing beta cells in the pancreatic islets by chemokine-attracted lymphocytes. Because islet cells in NOD mice produce chemokines during the development of autoimmune diabetes, we investigated the role of inflam...

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Veröffentlicht in:	Diabetologia 2011-07, Vol.54 (7), p.1777-1787
Hauptverfasser:	Lin, G.-J., Huang, S.-H., Chen, Y.-W., Hueng, D.-Y., Chia, W.-T., Chien, M.-W., Yen, B. L., Sytwu, H.-K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Autoimmune diseases B-Lymphocytes - immunology Biological and medical sciences Blotting, Western Chemokine Receptor D6 Chemokines Chemokines, CC - genetics Chemokines, CC - metabolism Diabetes Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Flow Cytometry Hospitals Human Physiology Insulin Internal Medicine Lymphatic system Lymphocytes Medical sciences Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Inbred NOD Pancreas Pathogenesis Receptors, CCR10 - genetics Receptors, CCR10 - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal transduction Surgery T-Lymphocytes - immunology
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