CD109 release from the cell surface in human keratinocytes regulates TGF-β receptor expression, TGF-β signalling and STAT3 activation: relevance to psoriasis

: Transforming growth factor (TGF)‐β is an important cytokine that negatively regulates keratinocyte proliferation. Deregulation of TGF‐β signalling has been reported in psoriasis, where despite increased expression of TGF‐β, psoriatic keratinocytes continue to hyperproliferate. Recently, we have i...

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Veröffentlicht in:	Experimental dermatology 2011-08, Vol.20 (8), p.627-632
Hauptverfasser:	Litvinov, Ivan V., Bizet, Albane A., Binamer, Yousef, Jones, David A., Sasseville, Denis, Philip, Anie
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - metabolism Bcl-2 protein Biological and medical sciences CD109 Cell Line Cell Membrane - metabolism Cell Proliferation Cell surface Cell survival Cell Survival - physiology Cytokines Dermatology Epidermis Gene expression GPI-Linked Proteins - metabolism Humans Keratinocytes Keratinocytes - cytology Keratinocytes - metabolism Medical sciences Neoplasm Proteins - metabolism phosphatidylinositol Plaques Proto-Oncogene Proteins c-bcl-2 - metabolism Psoriasis Psoriasis - metabolism Psoriasis - pathology Psoriasis - physiopathology Psoriasis. Parapsoriasis. Lichen Receptors, Transforming Growth Factor beta - metabolism Signal Transduction - physiology Skin STAT3 and glycosyl phosphatidylinositol-anchored proteins Stat3 protein STAT3 Transcription Factor - metabolism TGF-β Transforming growth factor Transforming Growth Factor beta - metabolism Transforming growth factor- beta
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