Pregnancy and tuberculosis: to assess tuberculosis cases in pregnancy in a developing region retrospectively and two case reports
Pregnancy and tuberculosis (TB) To assess TB cases during pregnancy in a developing region retrospectively and to present two case reports. Objectives Since TB cases activated by HIV infection during pregnancy are well reported in the literature, we aimed to investigate the aggressiveness of pulmona...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2008-11, Vol.278 (5), p.451-455 |
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| creator | Keskin, Nadi Yilmaz, Sema |
| description | Pregnancy and tuberculosis (TB)
To assess TB cases during pregnancy in a developing region retrospectively and to present two case reports.
Objectives
Since TB cases activated by HIV infection during pregnancy are well reported in the literature, we aimed to investigate the aggressiveness of pulmonary TB among pregnant women and to assess the effects of TB on the fetus in Kutahya, an area where HIV positive cases are not seen.
Materials and methods
The medical records between 2000 and 2005 of the Provincial Health Directorate and Dispensary Against Tuberculosis in Kutahya were reviewed and analyzed retrospectively.
Results
Between 2000 and 2005, 667 pulmonary TB cases were examined in the Kutahya region. Of these, 106 occurred in women at reproductive ages between 20 and 44. All were HIV negative cases. In this area, five TB cases were found during pregnancy. There were three cases seen in the first trimester, but pregnancy was ended by curettage. Two women had pulmonary TB and gave birth. Five cases were evaluated as class 1 TB. During and after pregnancy, isoniazid, rifampin, ethambutol, and pyrazinamide (INH + RFP + ETB + PRZ) were used for the treatment. Resistance to anti-TB drugs was not seen during the treatment. Neither congenial nor neonatal TB was seen.
Conclusion
Generally, TB is expected to be more aggressive during pregnancy. Since our cases were HIV negative, it can be thought that TB did not progress aggressively. Less aggressiveness and non-resistance to TB treatment in HIV-negative pregnant women compared with HIV-positive women were observed. Therefore, HIV infection results in greater mortality than the triple combination of human immunodeficiency virus, mycobacterium TB, and pregnancy. Besides, the advance of TB in pregnant women was not different from that in non-pregnant women in Kutahya. The fetus and the newborn were not affected. INH, RFP, ETB, and PRZ were used for therapy. |
| doi_str_mv | 10.1007/s00404-008-0594-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_907163702</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69516991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-6babecf71a7a97ae5bc963df1506341e6455f135d3d2a117b4ab2dc9b81ded593</originalsourceid><addsrcrecordid>eNp9kU1rFTEUhoNY7LX6A9xIQLCrqedk8jFxJ8UvKOhC1yGTZC5T5iZjMmPp0n9urvdiUWhXSc77nPeQ8xLyAuECAdSbAsCBNwBdA0LzRj0iG-Qta0AhPiYb0Ps7SHVKnpZyDYCs6-QTcoodU61kYkN-fc1hG210t9RGT5e1D9mtUypjeUuXRG0poZR_6tTZWqNjpPPf3vqw1IefYUrzGLe0CmOK9VhyKnNwy1il44ib9MehinPKS3lGTgY7lfD8eJ6R7x_ef7v81Fx9-fj58t1V4zgXSyN72wc3KLTKamWD6J2WrR9QgGw5BsmFGLAVvvXMIqqe2555p_sOffBCt2fk_OA75_RjDWUxu7G4ME02hrQWo-vSZKuAVfL1g6TUAqXWWMFX_4HXac2x_sIwJrHrNFNdpfBAubqLksNg5jzubL41CGafoznkaGqOZp-jUbXn5dF57XfB33Ucg6sAOwClSnEb8t3o-11_A7ZaqtA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261889278</pqid></control><display><type>article</type><title>Pregnancy and tuberculosis: to assess tuberculosis cases in pregnancy in a developing region retrospectively and two case reports</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Keskin, Nadi ; Yilmaz, Sema</creator><creatorcontrib>Keskin, Nadi ; Yilmaz, Sema</creatorcontrib><description>Pregnancy and tuberculosis (TB)
To assess TB cases during pregnancy in a developing region retrospectively and to present two case reports.
Objectives
Since TB cases activated by HIV infection during pregnancy are well reported in the literature, we aimed to investigate the aggressiveness of pulmonary TB among pregnant women and to assess the effects of TB on the fetus in Kutahya, an area where HIV positive cases are not seen.
Materials and methods
The medical records between 2000 and 2005 of the Provincial Health Directorate and Dispensary Against Tuberculosis in Kutahya were reviewed and analyzed retrospectively.
Results
Between 2000 and 2005, 667 pulmonary TB cases were examined in the Kutahya region. Of these, 106 occurred in women at reproductive ages between 20 and 44. All were HIV negative cases. In this area, five TB cases were found during pregnancy. There were three cases seen in the first trimester, but pregnancy was ended by curettage. Two women had pulmonary TB and gave birth. Five cases were evaluated as class 1 TB. During and after pregnancy, isoniazid, rifampin, ethambutol, and pyrazinamide (INH + RFP + ETB + PRZ) were used for the treatment. Resistance to anti-TB drugs was not seen during the treatment. Neither congenial nor neonatal TB was seen.
Conclusion
Generally, TB is expected to be more aggressive during pregnancy. Since our cases were HIV negative, it can be thought that TB did not progress aggressively. Less aggressiveness and non-resistance to TB treatment in HIV-negative pregnant women compared with HIV-positive women were observed. Therefore, HIV infection results in greater mortality than the triple combination of human immunodeficiency virus, mycobacterium TB, and pregnancy. Besides, the advance of TB in pregnant women was not different from that in non-pregnant women in Kutahya. The fetus and the newborn were not affected. INH, RFP, ETB, and PRZ were used for therapy.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-008-0594-7</identifier><identifier>PMID: 18273625</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Antitubercular Agents - therapeutic use ; Case reports ; Cohort Studies ; Developing Countries ; Endocrinology ; Female ; Fetuses ; Gynecology ; HIV ; Human Genetics ; Human immunodeficiency virus ; Humans ; Infectious Disease Transmission, Vertical - prevention & control ; Infectious Disease Transmission, Vertical - statistics & numerical data ; Medicine ; Medicine & Public Health ; Mycobacterium ; Obstetrics/Perinatology/Midwifery ; Original Article ; Pregnancy ; Pregnancy Complications, Infectious - diagnosis ; Pregnancy Complications, Infectious - epidemiology ; Pregnancy Complications, Infectious - therapy ; Retrospective Studies ; Treatment resistance ; Tuberculosis ; Tuberculosis, Pulmonary - diagnosis ; Tuberculosis, Pulmonary - epidemiology ; Tuberculosis, Pulmonary - therapy ; Turkey ; Young Adult</subject><ispartof>Archives of gynecology and obstetrics, 2008-11, Vol.278 (5), p.451-455</ispartof><rights>Springer-Verlag 2008</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2008). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-6babecf71a7a97ae5bc963df1506341e6455f135d3d2a117b4ab2dc9b81ded593</citedby><cites>FETCH-LOGICAL-c445t-6babecf71a7a97ae5bc963df1506341e6455f135d3d2a117b4ab2dc9b81ded593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-008-0594-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-008-0594-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18273625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keskin, Nadi</creatorcontrib><creatorcontrib>Yilmaz, Sema</creatorcontrib><title>Pregnancy and tuberculosis: to assess tuberculosis cases in pregnancy in a developing region retrospectively and two case reports</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Pregnancy and tuberculosis (TB)
To assess TB cases during pregnancy in a developing region retrospectively and to present two case reports.
Objectives
Since TB cases activated by HIV infection during pregnancy are well reported in the literature, we aimed to investigate the aggressiveness of pulmonary TB among pregnant women and to assess the effects of TB on the fetus in Kutahya, an area where HIV positive cases are not seen.
Materials and methods
The medical records between 2000 and 2005 of the Provincial Health Directorate and Dispensary Against Tuberculosis in Kutahya were reviewed and analyzed retrospectively.
Results
Between 2000 and 2005, 667 pulmonary TB cases were examined in the Kutahya region. Of these, 106 occurred in women at reproductive ages between 20 and 44. All were HIV negative cases. In this area, five TB cases were found during pregnancy. There were three cases seen in the first trimester, but pregnancy was ended by curettage. Two women had pulmonary TB and gave birth. Five cases were evaluated as class 1 TB. During and after pregnancy, isoniazid, rifampin, ethambutol, and pyrazinamide (INH + RFP + ETB + PRZ) were used for the treatment. Resistance to anti-TB drugs was not seen during the treatment. Neither congenial nor neonatal TB was seen.
Conclusion
Generally, TB is expected to be more aggressive during pregnancy. Since our cases were HIV negative, it can be thought that TB did not progress aggressively. Less aggressiveness and non-resistance to TB treatment in HIV-negative pregnant women compared with HIV-positive women were observed. Therefore, HIV infection results in greater mortality than the triple combination of human immunodeficiency virus, mycobacterium TB, and pregnancy. Besides, the advance of TB in pregnant women was not different from that in non-pregnant women in Kutahya. The fetus and the newborn were not affected. INH, RFP, ETB, and PRZ were used for therapy.</description><subject>Adult</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Case reports</subject><subject>Cohort Studies</subject><subject>Developing Countries</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fetuses</subject><subject>Gynecology</subject><subject>HIV</subject><subject>Human Genetics</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infectious Disease Transmission, Vertical - prevention & control</subject><subject>Infectious Disease Transmission, Vertical - statistics & numerical data</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mycobacterium</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Original Article</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - diagnosis</subject><subject>Pregnancy Complications, Infectious - epidemiology</subject><subject>Pregnancy Complications, Infectious - therapy</subject><subject>Retrospective Studies</subject><subject>Treatment resistance</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Pulmonary - diagnosis</subject><subject>Tuberculosis, Pulmonary - epidemiology</subject><subject>Tuberculosis, Pulmonary - therapy</subject><subject>Turkey</subject><subject>Young Adult</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1rFTEUhoNY7LX6A9xIQLCrqedk8jFxJ8UvKOhC1yGTZC5T5iZjMmPp0n9urvdiUWhXSc77nPeQ8xLyAuECAdSbAsCBNwBdA0LzRj0iG-Qta0AhPiYb0Ps7SHVKnpZyDYCs6-QTcoodU61kYkN-fc1hG210t9RGT5e1D9mtUypjeUuXRG0poZR_6tTZWqNjpPPf3vqw1IefYUrzGLe0CmOK9VhyKnNwy1il44ib9MehinPKS3lGTgY7lfD8eJ6R7x_ef7v81Fx9-fj58t1V4zgXSyN72wc3KLTKamWD6J2WrR9QgGw5BsmFGLAVvvXMIqqe2555p_sOffBCt2fk_OA75_RjDWUxu7G4ME02hrQWo-vSZKuAVfL1g6TUAqXWWMFX_4HXac2x_sIwJrHrNFNdpfBAubqLksNg5jzubL41CGafoznkaGqOZp-jUbXn5dF57XfB33Ucg6sAOwClSnEb8t3o-11_A7ZaqtA</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Keskin, Nadi</creator><creator>Yilmaz, Sema</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20081101</creationdate><title>Pregnancy and tuberculosis: to assess tuberculosis cases in pregnancy in a developing region retrospectively and two case reports</title><author>Keskin, Nadi ; Yilmaz, Sema</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-6babecf71a7a97ae5bc963df1506341e6455f135d3d2a117b4ab2dc9b81ded593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>Case reports</topic><topic>Cohort Studies</topic><topic>Developing Countries</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fetuses</topic><topic>Gynecology</topic><topic>HIV</topic><topic>Human Genetics</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infectious Disease Transmission, Vertical - prevention & control</topic><topic>Infectious Disease Transmission, Vertical - statistics & numerical data</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mycobacterium</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Original Article</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - diagnosis</topic><topic>Pregnancy Complications, Infectious - epidemiology</topic><topic>Pregnancy Complications, Infectious - therapy</topic><topic>Retrospective Studies</topic><topic>Treatment resistance</topic><topic>Tuberculosis</topic><topic>Tuberculosis, Pulmonary - diagnosis</topic><topic>Tuberculosis, Pulmonary - epidemiology</topic><topic>Tuberculosis, Pulmonary - therapy</topic><topic>Turkey</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keskin, Nadi</creatorcontrib><creatorcontrib>Yilmaz, Sema</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keskin, Nadi</au><au>Yilmaz, Sema</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy and tuberculosis: to assess tuberculosis cases in pregnancy in a developing region retrospectively and two case reports</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>278</volume><issue>5</issue><spage>451</spage><epage>455</epage><pages>451-455</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Pregnancy and tuberculosis (TB)
To assess TB cases during pregnancy in a developing region retrospectively and to present two case reports.
Objectives
Since TB cases activated by HIV infection during pregnancy are well reported in the literature, we aimed to investigate the aggressiveness of pulmonary TB among pregnant women and to assess the effects of TB on the fetus in Kutahya, an area where HIV positive cases are not seen.
Materials and methods
The medical records between 2000 and 2005 of the Provincial Health Directorate and Dispensary Against Tuberculosis in Kutahya were reviewed and analyzed retrospectively.
Results
Between 2000 and 2005, 667 pulmonary TB cases were examined in the Kutahya region. Of these, 106 occurred in women at reproductive ages between 20 and 44. All were HIV negative cases. In this area, five TB cases were found during pregnancy. There were three cases seen in the first trimester, but pregnancy was ended by curettage. Two women had pulmonary TB and gave birth. Five cases were evaluated as class 1 TB. During and after pregnancy, isoniazid, rifampin, ethambutol, and pyrazinamide (INH + RFP + ETB + PRZ) were used for the treatment. Resistance to anti-TB drugs was not seen during the treatment. Neither congenial nor neonatal TB was seen.
Conclusion
Generally, TB is expected to be more aggressive during pregnancy. Since our cases were HIV negative, it can be thought that TB did not progress aggressively. Less aggressiveness and non-resistance to TB treatment in HIV-negative pregnant women compared with HIV-positive women were observed. Therefore, HIV infection results in greater mortality than the triple combination of human immunodeficiency virus, mycobacterium TB, and pregnancy. Besides, the advance of TB in pregnant women was not different from that in non-pregnant women in Kutahya. The fetus and the newborn were not affected. INH, RFP, ETB, and PRZ were used for therapy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18273625</pmid><doi>10.1007/s00404-008-0594-7</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of gynecology and obstetrics, 2008-11, Vol.278 (5), p.451-455 |
| issn | 0932-0067 1432-0711 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Antitubercular Agents - therapeutic use Case reports Cohort Studies Developing Countries Endocrinology Female Fetuses Gynecology HIV Human Genetics Human immunodeficiency virus Humans Infectious Disease Transmission, Vertical - prevention & control Infectious Disease Transmission, Vertical - statistics & numerical data Medicine Medicine & Public Health Mycobacterium Obstetrics/Perinatology/Midwifery Original Article Pregnancy Pregnancy Complications, Infectious - diagnosis Pregnancy Complications, Infectious - epidemiology Pregnancy Complications, Infectious - therapy Retrospective Studies Treatment resistance Tuberculosis Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - therapy Turkey Young Adult |
| title | Pregnancy and tuberculosis: to assess tuberculosis cases in pregnancy in a developing region retrospectively and two case reports |
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