Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity

H. pylori beats PAR Helicobacter pylori infects more than half of the world's population, and though usually well tolerated, it can cause gastric mucosal damage, peptic ulcers, gastritis and adenocarcinoma. CagA is the main virulence factor of H. pylori , delivered directly by the bacterium int...

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Veröffentlicht in:	Nature 2007-05, Vol.447 (7142), p.330-333
Hauptverfasser:	Saadat, Iraj, Higashi, Hideaki, Obuse, Chikashi, Umeda, Mayumi, Murata-Kamiya, Naoko, Saito, Yasuhiro, Lu, Huaisheng, Ohnishi, Naomi, Azuma, Takeshi, Suzuki, Atsushi, Ohno, Shigeo, Hatakeyama, Masanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - genetics Antigens, Bacterial - metabolism Bacteria Bacterial diseases Bacterial diseases of the digestive system and abdomen Bacterial Proteins - genetics Bacterial Proteins - metabolism Biochemistry Biological and medical sciences Carcinogenesis Cell Line Cell Polarity Cellular biology Epithelial Cells - cytology Epithelial Cells - enzymology Epithelial Cells - pathology Gastrointestinal diseases General aspects Helicobacter pylori Human bacterial diseases Humanities and Social Sciences Humans Infectious diseases Intracellular Signaling Peptides and Proteins - metabolism Kinases letter Medical sciences multidisciplinary Phosphorylation Polarity Protein Structure, Quaternary Protein Tyrosine Phosphatase, Non-Receptor Type 11 Protein Tyrosine Phosphatases - metabolism Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Science Science (multidisciplinary) Tight Junctions - metabolism Tissues
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