Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas

Recent studies have suggested that APC loss alone may be insufficient to promote aberrant Wnt/β-catenin signalling. Our aim was to comprehensively characterize Wnt signalling components in a set of APC-associated familial adenomatous polyposis (FAP) tumours. Sixty adenomas from six FAP patients with...

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Veröffentlicht in:	The Journal of pathology 2010-05, Vol.221 (1), p.57-67
Hauptverfasser:	Obrador-Hevia, Antònia, Chin, Suet-Feung, González, Sara, Rees, Jonathan, Vilardell, Felip, Greenson, Joel K, Cordero, David, Moreno, Víctor, Caldas, Carlos, Capellá, Gabriel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli - metabolism Adenomatous Polyposis Coli Protein - biosynthesis Adenomatous Polyposis Coli Protein - genetics Adult APC beta Catenin - metabolism Biological and medical sciences catenin Cell Nucleus - metabolism Chromosomes colorectal cancer Comparative Genomic Hybridization copy number DNA Familial adenomatous polyposis Female Frizzled-related protein 1 Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Genes, APC Genetic Predisposition to Disease genomic profiling genomics Germ-Line Mutation Humans Investigative techniques, diagnostic techniques (general aspects) K-Ras protein Loss of Heterozygosity Male Medical sciences mRNA Myc protein Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Point mutation Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins p21(ras) ras Proteins - genetics ras Proteins - physiology Signal transduction Signal Transduction - physiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumorigenesis Tumors Wnt protein Wnt Proteins - physiology Wnt signalling Young Adult
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