Evaluation of the Xpert™ MRSA/SA Blood Culture assay for the detection of Staphylococcus aureus including strains with reduced vancomycin susceptibility from blood culture specimens
Abstract The Xpert MRSA/SA Blood Culture (BC) assay (Cepheid, Sunnyvale, CA) was prospectively compared to culture and found to have excellent specificity for both Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in BC specimens with a sensitivity of 75% (3/4) and 100% (17/17), respe...
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| Veröffentlicht in: | Diagnostic microbiology and infectious disease 2011-07, Vol.70 (3), p.404-407 |
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| container_title | Diagnostic microbiology and infectious disease |
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| creator | Kelley, Peter G Grabsch, Elizabeth A Farrell, Jenny Xie, Shirley Montgomery, Janet Mayall, Barrie Howden, Benjamin P |
| description | Abstract The Xpert MRSA/SA Blood Culture (BC) assay (Cepheid, Sunnyvale, CA) was prospectively compared to culture and found to have excellent specificity for both Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in BC specimens with a sensitivity of 75% (3/4) and 100% (17/17), respectively. Among 28 heterogeneous vancomycin-intermediate S. aureus (hVISA)/VISA spiked BCs, the assay correctly identified 84.6% VISA and 80% hVISA isolates as MRSA. |
| doi_str_mv | 10.1016/j.diagmicrobio.2011.02.006 |
| format | Article |
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Psychology ; GeneXpert ; Humans ; Infectious Disease ; Infectious diseases ; Internal Medicine ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; PCR ; Sensitivity and Specificity ; Staphylococcal Infections - microbiology ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - isolation & purification ; Vancomycin - pharmacology ; Young Adult</subject><ispartof>Diagnostic microbiology and infectious disease, 2011-07, Vol.70 (3), p.404-407</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. 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Among 28 heterogeneous vancomycin-intermediate S. aureus (hVISA)/VISA spiked BCs, the assay correctly identified 84.6% VISA and 80% hVISA isolates as MRSA.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bacteremia - microbiology</subject><subject>Bacteriological Techniques - methods</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Blood - microbiology</subject><subject>Blood culture</subject><subject>Drug Resistance, Bacterial</subject><subject>Fundamental and applied biological sciences. 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| subjects | Adolescent Adult Aged Aged, 80 and over Bacteremia - microbiology Bacteriological Techniques - methods Bacteriology Biological and medical sciences Blood - microbiology Blood culture Drug Resistance, Bacterial Fundamental and applied biological sciences. Psychology GeneXpert Humans Infectious Disease Infectious diseases Internal Medicine Medical sciences Microbiology Middle Aged Miscellaneous PCR Sensitivity and Specificity Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - isolation & purification Vancomycin - pharmacology Young Adult |
| title | Evaluation of the Xpert™ MRSA/SA Blood Culture assay for the detection of Staphylococcus aureus including strains with reduced vancomycin susceptibility from blood culture specimens |
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