Targeting Anaplastic Lymphoma Kinase in Lung Cancer

Several decades of cancer research have revealed a pivotal role for tyrosine kinases as key regulators of signaling pathways, controlling cell growth and differentiation. Deregulation of tyrosine kinase-mediated signaling occurs frequently in cancer and is believed to drive the initiation and progre...

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Veröffentlicht in:	Clinical cancer research 2011-04, Vol.17 (8), p.2081-2086
Hauptverfasser:	SHAW, Alice T, SOLOMON, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - genetics Humans Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Lung Neoplasms - genetics Lung Neoplasms - pathology Medical sciences Models, Biological Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Pharmacology. Drug treatments Pneumology Protein Kinase Inhibitors - therapeutic use Pyrazoles - therapeutic use Pyridines - therapeutic use Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Signal Transduction - drug effects Tumors of the respiratory system and mediastinum
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