New aspects of drug-induced hypersensitivity syndrome
Drug‐induced hypersensitivity syndrome (DIHS) is caused by a limited number of specific drugs and is characterized by late onset, infectious mononucleosis‐like symptoms, and herpesvirus 6 (HHV‐6) reactivation. Recently, the involvement of herpes viruses other than HHV‐6, such as Epstein–Barr virus a...
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| Veröffentlicht in: | Journal of dermatology 2011-03, Vol.38 (3), p.222-228 |
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| creator | TOHYAMA, Mikiko HASHIMOTO, Koji |
| description | Drug‐induced hypersensitivity syndrome (DIHS) is caused by a limited number of specific drugs and is characterized by late onset, infectious mononucleosis‐like symptoms, and herpesvirus 6 (HHV‐6) reactivation. Recently, the involvement of herpes viruses other than HHV‐6, such as Epstein–Barr virus and cytomegalovirus, has been reported. Many approaches have been used to analyze the pathological mechanism, and have revealed new aspects of DIHS. Here, we focused on three key recent findings regarding DIHS: (i) overlap between DIHS and Stevens–Johnson syndrome/toxic epidermal necrolysis; (ii) the relevance of Epstein–Barr virus in the development of infectious mononucleosis‐like symptoms of DIHS; and (iii) roles of monomyeloid precursors increased in the blood and plasmacytoid dendritic cells increased in the lesion skin in HHV‐6 reactivation. |
| doi_str_mv | 10.1111/j.1346-8138.2010.01176.x |
| format | Article |
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Here, we focused on three key recent findings regarding DIHS: (i) overlap between DIHS and Stevens–Johnson syndrome/toxic epidermal necrolysis; (ii) the relevance of Epstein–Barr virus in the development of infectious mononucleosis‐like symptoms of DIHS; and (iii) roles of monomyeloid precursors increased in the blood and plasmacytoid dendritic cells increased in the lesion skin in HHV‐6 reactivation.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/j.1346-8138.2010.01176.x</identifier><identifier>PMID: 21342223</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Blood ; Cytomegalovirus ; Dendritic cells ; Dendritic Cells - virology ; Drug Hypersensitivity - diagnosis ; Drug Hypersensitivity - virology ; drug-induced hypersensitivity syndrome ; Drugs ; Epstein-Barr virus ; Epstein-Barr Virus Infections - complications ; Hemopoiesis ; Herpes simplex ; Herpesviridae Infections - complications ; Herpesvirus ; Herpesvirus 4, Human - pathogenicity ; herpesvirus 6 ; Herpesvirus 6, Human - physiology ; Human herpesvirus 6 ; Humans ; Hypersensitivity ; Infectious Mononucleosis - complications ; Myeloid Cells - virology ; Skin diseases ; Stem cells ; Stevens-Johnson syndrome ; Stevens-Johnson Syndrome - diagnosis ; Syndrome ; Toxic epidermal necrolysis ; Virus Activation</subject><ispartof>Journal of dermatology, 2011-03, Vol.38 (3), p.222-228</ispartof><rights>2011 Japanese Dermatological Association</rights><rights>2011 Japanese Dermatological Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5576-581eb1b6fd55fd1d01bad22f0c01d2175c49e756335db1e3488c0d4afbde14303</citedby><cites>FETCH-LOGICAL-c5576-581eb1b6fd55fd1d01bad22f0c01d2175c49e756335db1e3488c0d4afbde14303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1346-8138.2010.01176.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1346-8138.2010.01176.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21342223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TOHYAMA, Mikiko</creatorcontrib><creatorcontrib>HASHIMOTO, Koji</creatorcontrib><title>New aspects of drug-induced hypersensitivity syndrome</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>Drug‐induced hypersensitivity syndrome (DIHS) is caused by a limited number of specific drugs and is characterized by late onset, infectious mononucleosis‐like symptoms, and herpesvirus 6 (HHV‐6) reactivation. 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| identifier | ISSN: 0385-2407 |
| ispartof | Journal of dermatology, 2011-03, Vol.38 (3), p.222-228 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Blood Cytomegalovirus Dendritic cells Dendritic Cells - virology Drug Hypersensitivity - diagnosis Drug Hypersensitivity - virology drug-induced hypersensitivity syndrome Drugs Epstein-Barr virus Epstein-Barr Virus Infections - complications Hemopoiesis Herpes simplex Herpesviridae Infections - complications Herpesvirus Herpesvirus 4, Human - pathogenicity herpesvirus 6 Herpesvirus 6, Human - physiology Human herpesvirus 6 Humans Hypersensitivity Infectious Mononucleosis - complications Myeloid Cells - virology Skin diseases Stem cells Stevens-Johnson syndrome Stevens-Johnson Syndrome - diagnosis Syndrome Toxic epidermal necrolysis Virus Activation |
| title | New aspects of drug-induced hypersensitivity syndrome |
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