Spondyloarthritis and rheumatoid arthritis: different clinical manifestations, similar cytokine network
Background The reasons for the phenotypic differences between spondyloarthritis (SpA) and rheumatoid arthritis (RA) are still unclear. Slight divergences in cytokine networks driving the pathologies might contribute to the distinct clinical manifestations and may represent new treatment opportunitie...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2011-03, Vol.70 (Suppl 2), p.A82-A83 |
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| creator | Moura, RA Cascão, R Perpétuo, I Canhão, H Vieira-Sousa, E Mourão, AF Rodrigues, AM Polido-Pereira, J da Silva, JA Pereira Rosário, HS Souto-Carneiro, MM Graça, L Fonseca, JE |
| description | Background The reasons for the phenotypic differences between spondyloarthritis (SpA) and rheumatoid arthritis (RA) are still unclear. Slight divergences in cytokine networks driving the pathologies might contribute to the distinct clinical manifestations and may represent new treatment opportunities. Objectives The main goal of this work was to compare serum and synovial cytokines in established SpA and RA patients. Materials and methods The concentration of a panel of cytokines was measured in the serum of SpA and RA patients, as well as in synovial fluid from SpA, RA and osteoarthritis patients. Results The authors found that SpA and RA patients shared a similar pattern of cytokine concentration, with the exception of higher levels of interleukin-21 in the synovial fluid of RA patients. Conclusions Our results suggest that although SpA and RA are chronic inflammatory diseases with clearly distinct clinical manifestations, both pathologies share a similar cytokine profile, including Th17-related cytokines. |
| doi_str_mv | 10.1136/ard.2010.149021.2 |
| format | Article |
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Slight divergences in cytokine networks driving the pathologies might contribute to the distinct clinical manifestations and may represent new treatment opportunities. Objectives The main goal of this work was to compare serum and synovial cytokines in established SpA and RA patients. Materials and methods The concentration of a panel of cytokines was measured in the serum of SpA and RA patients, as well as in synovial fluid from SpA, RA and osteoarthritis patients. Results The authors found that SpA and RA patients shared a similar pattern of cytokine concentration, with the exception of higher levels of interleukin-21 in the synovial fluid of RA patients. Conclusions Our results suggest that although SpA and RA are chronic inflammatory diseases with clearly distinct clinical manifestations, both pathologies share a similar cytokine profile, including Th17-related cytokines.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.2010.149021.2</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>Kidlington: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><ispartof>Annals of the rheumatic diseases, 2011-03, Vol.70 (Suppl 2), p.A82-A83</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2011 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/70/Suppl_2/A82.2.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/70/Suppl_2/A82.2.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3182,23551,27903,27904,77346,77377</link.rule.ids></links><search><creatorcontrib>Moura, RA</creatorcontrib><creatorcontrib>Cascão, R</creatorcontrib><creatorcontrib>Perpétuo, I</creatorcontrib><creatorcontrib>Canhão, H</creatorcontrib><creatorcontrib>Vieira-Sousa, E</creatorcontrib><creatorcontrib>Mourão, AF</creatorcontrib><creatorcontrib>Rodrigues, AM</creatorcontrib><creatorcontrib>Polido-Pereira, J</creatorcontrib><creatorcontrib>da Silva, JA Pereira</creatorcontrib><creatorcontrib>Rosário, HS</creatorcontrib><creatorcontrib>Souto-Carneiro, MM</creatorcontrib><creatorcontrib>Graça, L</creatorcontrib><creatorcontrib>Fonseca, JE</creatorcontrib><title>Spondyloarthritis and rheumatoid arthritis: different clinical manifestations, similar cytokine network</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>Background The reasons for the phenotypic differences between spondyloarthritis (SpA) and rheumatoid arthritis (RA) are still unclear. Slight divergences in cytokine networks driving the pathologies might contribute to the distinct clinical manifestations and may represent new treatment opportunities. Objectives The main goal of this work was to compare serum and synovial cytokines in established SpA and RA patients. Materials and methods The concentration of a panel of cytokines was measured in the serum of SpA and RA patients, as well as in synovial fluid from SpA, RA and osteoarthritis patients. Results The authors found that SpA and RA patients shared a similar pattern of cytokine concentration, with the exception of higher levels of interleukin-21 in the synovial fluid of RA patients. Conclusions Our results suggest that although SpA and RA are chronic inflammatory diseases with clearly distinct clinical manifestations, both pathologies share a similar cytokine profile, including Th17-related cytokines.</description><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkDuvEzEUhC0EEiHwA-gsUdBkg1_rBx2KLgQIoeBR0FiO1yZOdu1c2xHk37PRohRUVEej881oNAA8x2iJMeWvTO6WBF0VU4jgJXkAZphx2RDE0UMwQwjRhikuHoMnpRxGiSSWM_DzyynF7tInk-s-hxoKNLGDee_Og6kpdPD2eA274L3LLlZo-xCDNT0cTAzelWpqSLEsYAlD6E2G9lLTMUQHo6u_Uj4-BY-86Yt79vfOwbe3d19X62bz-d371ZtNsyMEkcZ3gghplfKOtZZT4YVtPbJe0lZx3ilB2x0jRKFda4jAknljJZOuk5JhKukcvJxyTzndn8diegjFur430aVz0QoJzBFmZCRf_EMe0jnHsZzGQgjJFVVqpPBE2ZxKyc7rUw6DyReNkb4ur8fl9XV5PS2vr8nN5Amlut83g8lHzQUVrd5-X-lPayHZhx9b_XHkFxO_Gw7_Ef8HsAWUww</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Moura, RA</creator><creator>Cascão, R</creator><creator>Perpétuo, I</creator><creator>Canhão, H</creator><creator>Vieira-Sousa, E</creator><creator>Mourão, AF</creator><creator>Rodrigues, AM</creator><creator>Polido-Pereira, J</creator><creator>da Silva, JA Pereira</creator><creator>Rosário, HS</creator><creator>Souto-Carneiro, MM</creator><creator>Graça, L</creator><creator>Fonseca, JE</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>Elsevier Limited</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20110301</creationdate><title>Spondyloarthritis and rheumatoid arthritis: different clinical manifestations, similar cytokine network</title><author>Moura, RA ; Cascão, R ; Perpétuo, I ; Canhão, H ; Vieira-Sousa, E ; Mourão, AF ; Rodrigues, AM ; Polido-Pereira, J ; da Silva, JA Pereira ; Rosário, HS ; Souto-Carneiro, MM ; Graça, L ; Fonseca, JE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b2202-fd7278c99fe45c637f7c5f0cf835966d9735b42290b5a27184fac848ed8841383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moura, RA</creatorcontrib><creatorcontrib>Cascão, R</creatorcontrib><creatorcontrib>Perpétuo, I</creatorcontrib><creatorcontrib>Canhão, H</creatorcontrib><creatorcontrib>Vieira-Sousa, E</creatorcontrib><creatorcontrib>Mourão, AF</creatorcontrib><creatorcontrib>Rodrigues, AM</creatorcontrib><creatorcontrib>Polido-Pereira, J</creatorcontrib><creatorcontrib>da Silva, JA Pereira</creatorcontrib><creatorcontrib>Rosário, HS</creatorcontrib><creatorcontrib>Souto-Carneiro, MM</creatorcontrib><creatorcontrib>Graça, L</creatorcontrib><creatorcontrib>Fonseca, JE</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moura, RA</au><au>Cascão, R</au><au>Perpétuo, I</au><au>Canhão, H</au><au>Vieira-Sousa, E</au><au>Mourão, AF</au><au>Rodrigues, AM</au><au>Polido-Pereira, J</au><au>da Silva, JA Pereira</au><au>Rosário, HS</au><au>Souto-Carneiro, MM</au><au>Graça, L</au><au>Fonseca, JE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spondyloarthritis and rheumatoid arthritis: different clinical manifestations, similar cytokine network</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>70</volume><issue>Suppl 2</issue><spage>A82</spage><epage>A83</epage><pages>A82-A83</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Background The reasons for the phenotypic differences between spondyloarthritis (SpA) and rheumatoid arthritis (RA) are still unclear. Slight divergences in cytokine networks driving the pathologies might contribute to the distinct clinical manifestations and may represent new treatment opportunities. Objectives The main goal of this work was to compare serum and synovial cytokines in established SpA and RA patients. Materials and methods The concentration of a panel of cytokines was measured in the serum of SpA and RA patients, as well as in synovial fluid from SpA, RA and osteoarthritis patients. Results The authors found that SpA and RA patients shared a similar pattern of cytokine concentration, with the exception of higher levels of interleukin-21 in the synovial fluid of RA patients. Conclusions Our results suggest that although SpA and RA are chronic inflammatory diseases with clearly distinct clinical manifestations, both pathologies share a similar cytokine profile, including Th17-related cytokines.</abstract><cop>Kidlington</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><doi>10.1136/ard.2010.149021.2</doi><oa>free_for_read</oa></addata></record> |
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| title | Spondyloarthritis and rheumatoid arthritis: different clinical manifestations, similar cytokine network |
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