Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population

We performed a three-stage genome-wide association study (GWAS) to identify common Parkinson's disease (PD) risk variants in the European population. The initial genome-wide scan was conducted in a French sample of 1039 cases and 1984 controls, using almost 500 000 single nucleotide polymorphis...

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Veröffentlicht in:	Human molecular genetics 2011-02, Vol.20 (3), p.615-627
Hauptverfasser:	SAAD, Mohamad, LESAGE, Suzanne, POLLAK, Pierre, DAMIER, Philippe, TISON, François, SILBURN, Peter A, TZOURIO, Christophe, FORIANI, Sylvie, LORIOT, Marie-Anne, GIROUD, Maurice, HELMER, Catherine, PORTET, Florence, SAINT-PIERRE, Aude, AMOUYEL, Philippe, LATHROP, Mark, ELBAZ, Alexis, DURR, Alexandra, MARTINEZ, Maria, BRICE, Alexis, CORVOL, Jean-Christophe, ZELENIKA, Diana, LAMBERT, Jean-Charles, VIDAILHET, Marie, MELLICK, George D, LOHMANN, Ebba, DURIF, Franck
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase - genetics Adult Aged Antigens, CD - genetics Biological and medical sciences Brain Case-Control Studies Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 4 Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Europe - epidemiology Female Fundamental and applied biological sciences. Psychology Genetic Loci Genetic Predisposition to Disease Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Genotype GPI-Linked Proteins - genetics Humans Male Medical sciences Middle Aged Molecular and cellular biology Neurology Parkinson Disease - epidemiology Parkinson Disease - genetics Polymorphism, Single Nucleotide Risk Factors Transcription Factors
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