Mucosal allergic sensitization to cockroach allergens is dependent on proteinase activity and proteinase-activated receptor-2 activation

We have shown that proteinase-activated receptor-2 (PAR(2)) activation in the airways leads to allergic sensitization to concomitantly inhaled Ags, thus implicating PAR(2) in the pathogenesis of asthma. Many aeroallergens with proteinase activity activate PAR(2). To study the role of PAR(2) in aller...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-03, Vol.186 (5), p.3164-3172
Hauptverfasser:	Arizmendi, Narcy G, Abel, Melanie, Mihara, Koichiro, Davidson, Courtney, Polley, Danny, Nadeem, Ahmed, El Mays, Tamer, Gilmore, Brendan F, Walker, Brian, Gordon, John R, Hollenberg, Morley D, Vliagoftis, Harissios
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - physiology Administration, Intranasal Allergens - administration & dosage Allergens - immunology Animals Blattellidae - enzymology Blattellidae - immunology Bronchial Hyperreactivity - enzymology Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - metabolism Cell Line, Transformed Disease Models, Animal Enzyme Activation - immunology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Nasal Mucosa - enzymology Nasal Mucosa - immunology Nasal Mucosa - metabolism Rats Receptor, PAR-2 - deficiency Receptor, PAR-2 - immunology Receptor, PAR-2 - metabolism Respiratory Hypersensitivity - enzymology Respiratory Hypersensitivity - immunology Respiratory Hypersensitivity - metabolism
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