Loss of Cited2 causes congenital heart disease by perturbing left―right patterning of the body axis

Cited2 is a transcriptional coactivator that is required for normal development of the embryo and placenta. Cited2-null mice die during gestation with fully penetrant heart defects and partially penetrant laterality defects. The laterality defects occur due to the loss of Nodal expression in the lef...

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Veröffentlicht in:	Human molecular genetics 2011-03, Vol.20 (6), p.1097-1110
Hauptverfasser:	LOPES FLORO, Kylie, ARTAP, Stanley T, PREIS, Jost I, FATKIN, Diane, CHAPMAN, Gavin, FURTADO, Milena B, HARVEY, Richard P, HAMADA, Hiroshi, SPARROW, Duncan B, DUNWOODIE, Sally L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Patterning Bone Morphogenetic Proteins - metabolism Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Heart - embryology Heart Defects, Congenital - embryology Heart Defects, Congenital - genetics Heart Defects, Congenital - metabolism Heart Defects, Congenital - physiopathology Humans Male Mesoderm - embryology Mesoderm - metabolism Mice Mice, Inbred C57BL Mice, Knockout Molecular and cellular biology Myocardium - metabolism Repressor Proteins - deficiency Repressor Proteins - genetics Signal Transduction Trans-Activators - deficiency Trans-Activators - genetics
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