CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

The Toll-like receptor (TLR) 9 ligand CpG has been used successfully for the immunotherapy of cancer. Chronic CpG application in tumor-free hosts leads, however, to the expansion of myeloid-derived suppressor cells (MDSC), which can cause T-cell suppression and may thus hamper the development of an...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2011-04, Vol.17 (7), p.1765-1775
Hauptverfasser:	ZOGLMEIER, Christine, BAUER, Helen, NÖRENBERG, Daniel, WEDEKIND, Georg, BITTNER, Philipp, SANDHOLZER, Nadja, RAPP, Moritz, ANZ, David, ENDRES, Stefan, BOURQUIN, Carole
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation - metabolism Antigens, Ly - metabolism Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological and medical sciences Bone Marrow Cells - cytology Bone Marrow Cells - drug effects CD11b Antigen - metabolism Cell Differentiation Cell Proliferation - drug effects Cells, Cultured CpG Islands DNA - pharmacology DNA - therapeutic use Female Immune Tolerance - drug effects Immunologic Factors - pharmacology Immunologic Factors - therapeutic use Interferon-alpha - metabolism Interleukin-2 - metabolism Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Myeloid Cells - drug effects Myeloid Cells - immunology Myeloid Cells - pathology Oligodeoxyribonucleotides Pharmacology. Drug treatments Spleen - cytology Stomach Neoplasms - drug therapy Stomach Neoplasms - immunology Stomach Neoplasms - pathology Toll-Like Receptor 9 - agonists Tumor Burden - drug effects Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!