Sildenafil adjunctive therapy to risperidone in the treatment of the negative symptoms of schizophrenia: a double-blind randomized placebo-controlled trial

Rational It has been suggested that phosphodiesterase 5 inhibitors such as sildenafil may be effective in the treatment of negative symptoms of schizophrenia. Objective This study was designed to investigate the effect of sildenafil added to risperidone as augmentation therapy in patients with chron...

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Veröffentlicht in:	Psychopharmacologia 2011-02, Vol.213 (4), p.809-815
Hauptverfasser:	Akhondzadeh, Shahin, Ghayyoumi, Raofeh, Rezaei, Farzin, Salehi, Bahman, Modabbernia, Amir-Hossein, Maroufi, Azad, Esfandiari, Gholam-Reza, Naderi, Mehrangiz, Ghebleh, Fariba, Tabrizi, Mina, Rezazadeh, Shams-Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adult and adolescent clinical studies Antipsychotic Agents - administration & dosage Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Clinical outcomes Clinical trials Double-Blind Method Drug therapy Drug Therapy, Combination Female Humans Male Medical sciences Middle Aged Neuropharmacology Neurosciences Original Investigation Pharmacology. Drug treatments Pharmacology/Toxicology Phosphodiesterase 5 Inhibitors - administration & dosage Phosphodiesterase 5 Inhibitors - adverse effects Phosphodiesterase 5 Inhibitors - therapeutic use Piperazines - administration & dosage Piperazines - adverse effects Piperazines - therapeutic use Prospective Studies Psychiatric Status Rating Scales Psychiatry Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Psychotropic drugs Purines - administration & dosage Purines - adverse effects Purines - therapeutic use Risperidone - administration & dosage Risperidone - adverse effects Risperidone - therapeutic use Schizophrenia Schizophrenia - drug therapy Schizophrenia - physiopathology Schizophrenic Psychology Sildenafil Citrate Sulfones - administration & dosage Sulfones - adverse effects Sulfones - therapeutic use Young Adult
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