Critical Scaffolding Regions of the Tumor Suppressor Axin1 Are Natively Unfolded

The Wnt pathway tumor-suppressor protein Axin coordinates the formation of a critical multiprotein destruction complex that serves to downregulate β-catenin protein levels, thereby preventing target gene activation. Given the lack of structural information on some of the major functional parts of Ax...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular biology 2011-01, Vol.405 (3), p.773-786
Hauptverfasser:	Noutsou, Maria, Duarte, Afonso M.S., Anvarian, Zeinab, Didenko, Tatiana, Minde, David P., Kuper, Ineke, de Ridder, Isabel, Oikonomou, Christina, Friedler, Assaf, Boelens, Rolf, Rüdiger, Stefan G.D., Maurice, Madelon M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Axin Axin Protein beta Catenin - chemistry Binding Sites gene activation glycogen Glycogen Synthase Kinase 3 - chemistry Glycogen Synthase Kinase 3 beta Humans kinases Matrix Attachment Regions Models, Molecular natively unfolded phosphorylation Protein Binding Protein Unfolding Repressor Proteins - chemistry scaffold Tumor Suppressor Proteins - chemistry Wnt pathway Wnt Proteins - chemistry Wnt Proteins - metabolism β-catenin degradation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!