Nitric oxide stimulates NCX1 and NCX2 but inhibits NCX3 isoform by three distinct molecular determinants

In this study, the role of nitric oxide (NO) in the modulation of the activity of NCX1, NCX2, and NCX3 exchangers was investigated in baby hamster kidney cells singly transfected with each of these isoforms by single-cell Fura-2-microfluorometry and patch clamp. Furthermore, the molecular determinan...

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Veröffentlicht in:	Molecular pharmacology 2011-03, Vol.79 (3), p.558-568
Hauptverfasser:	Secondo, Agnese, Molinaro, Pasquale, Pannaccione, Anna, Esposito, Alba, Cantile, Maria, Lippiello, Pellegrino, Sirabella, Rossana, Iwamoto, Takahiro, Di Renzo, Gianfranco, Annunziato, Lucio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Blotting, Western Calcium - metabolism Cell Line Cricetinae Flow Cytometry Kidney - cytology Membrane Potentials - drug effects Mutagenesis, Site-Directed Nitric Oxide - pharmacology Patch-Clamp Techniques Protein Isoforms - drug effects S-Nitroso-N-Acetylpenicillamine - pharmacology Sodium-Calcium Exchanger - drug effects
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