ICER Evokes Dusp1-p38 Pathway Enhancing Chemotherapy Sensitivity in Myeloid Leukemia

The inducible cyclic adenosine monophosphate (cAMP) early repressor (ICER) is found downregulated in acute myeloid leukemia (AML), failing to control cAMP response element binding protein (CREB) transcriptional activity, recently demonstrated to mediate AML progression. We aimed to characterize ICER...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2011-02, Vol.17 (4), p.742-752
Hauptverfasser:	PIGAZZI, Martina, MANARA, Elena, BEGHIN, Alessandra, BARON, Emma, TREGNAGO, Claudia, BASSO, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Survival - drug effects Cyclic AMP Response Element Modulator - metabolism Down-Regulation Doxorubicin - pharmacology Dual Specificity Phosphatase 1 - genetics Dual Specificity Phosphatase 1 - physiology Dual-Specificity Phosphatases - genetics Enzyme Activation Etoposide - pharmacology Hematologic and hematopoietic diseases Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Leukemia, Myeloid - metabolism Leukemia, Myeloid - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Mitogen-Activated Protein Kinase Phosphatases - genetics p38 Mitogen-Activated Protein Kinases - physiology Pharmacology. Drug treatments Recombinant Proteins - metabolism RNA Interference Staurosporine - pharmacology Transcription, Genetic Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!