Putative IgG4-related pituitary disease with hypopituitarism and/or diabetes insipidus accompanied with elevated serum levels of IgG4
IgG4-positive plasma cell infiltration into multiple organs or tissues, such as the pancreas and salivary glands, associated with increased serum levels of IgG4 is a characteristic finding seen in IgG4-related disease. Affected organs may appear tumorous as a result of chronic inflammatory processes...
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| Veröffentlicht in: | Endocrine Journal 2010, Vol.57(8), pp.719-725 |
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| container_issue | 8 |
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| container_title | Endocrine Journal |
| container_volume | 57 |
| creator | Haraguchi, Ai Era, Ai Yasui, Junichi Ando, Takao Ueki, Ikuko Horie, Ichiro Imaizumi, Misa Usa, Toshiro Abe, Kuniko Origuchi, Tomoki Eguchi, Katsumi |
| description | IgG4-positive plasma cell infiltration into multiple organs or tissues, such as the pancreas and salivary glands, associated with increased serum levels of IgG4 is a characteristic finding seen in IgG4-related disease. Affected organs may appear tumorous as a result of chronic inflammatory processes accompanied with progressive fibrosis. Recent cases of this disorder in which the pituitary gland was affected include cases of diffuse enlargement of the pituitary and/or its stalk associated with central diabetes insipidus and/or impaired anterior hormone production. Here we report two such cases, as well as two additional previously undiagnosed cases found in our database. In order to make a correct diagnosis of pituitary lesion involvement with IgG4-related disease, the clinical background and concomitant disorders should be carefully taken into consideration and the measurement of serum levels of IgG4 seems to be useful. |
| doi_str_mv | 10.1507/endocrj.K10E-030 |
| format | Article |
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Affected organs may appear tumorous as a result of chronic inflammatory processes accompanied with progressive fibrosis. Recent cases of this disorder in which the pituitary gland was affected include cases of diffuse enlargement of the pituitary and/or its stalk associated with central diabetes insipidus and/or impaired anterior hormone production. Here we report two such cases, as well as two additional previously undiagnosed cases found in our database. In order to make a correct diagnosis of pituitary lesion involvement with IgG4-related disease, the clinical background and concomitant disorders should be carefully taken into consideration and the measurement of serum levels of IgG4 seems to be useful.</description><subject>Aged</subject><subject>Diabetes insipidus</subject><subject>Diabetes Insipidus - complications</subject><subject>Diabetes Insipidus - diagnosis</subject><subject>Diabetes Insipidus - immunology</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Hypopituitarism</subject><subject>Hypopituitarism - complications</subject><subject>Hypopituitarism - diagnosis</subject><subject>Hypopituitarism - immunology</subject><subject>IgG4</subject><subject>Immunoglobulin G - blood</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Pituitary</subject><subject>Pituitary Hormones - blood</subject><subject>Prednisolone - therapeutic use</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkbtuFTEURS0EIpckfarIHdUkfo7HJYqSEBEJCqgtj-c411fzwvYE5QP4b3yfLY0ty2uvI52N0BUlN1QSdQtjN7m4uflGyX1FOHmHVpSLphJSkPdoRTRtqkZLfYY-pbQhhHMp-Ed0xoioFa3pCv39sWSbwyvgp5dHUUXobYYOzyEvIdv4hruQwCbAf0Je4_XbPB2_QhqwHbvbKRbGtpAh4TCmMIduSdg6Nw2zHUOR7aLQw-tOnSAuAy4v6BOe_G7uBfrgbZ_g8nCfo18P9z_vvlbP3x-f7r48V04ymSvPiBMN90zUnmvlnWtqK2rOmKedcB5apjvdskYSB5xr2raeqoZppoC1QPg5-rz3znH6vUDKZgjJQd_bEaYlGU0UlUKVJf2PLAxhgildSLInXZxSiuDNHMNQVmcoMduWzKEls23JlJZK5PogX9oBulPgWEsBHvbAJmX7AifAxhxcDyejVKbZHkfzCXBrGwvF_wF8Lata</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Haraguchi, Ai</creator><creator>Era, Ai</creator><creator>Yasui, Junichi</creator><creator>Ando, Takao</creator><creator>Ueki, Ikuko</creator><creator>Horie, Ichiro</creator><creator>Imaizumi, Misa</creator><creator>Usa, Toshiro</creator><creator>Abe, Kuniko</creator><creator>Origuchi, Tomoki</creator><creator>Eguchi, Katsumi</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>2010</creationdate><title>Putative IgG4-related pituitary disease with hypopituitarism and/or diabetes insipidus accompanied with elevated serum levels of IgG4</title><author>Haraguchi, Ai ; Era, Ai ; Yasui, Junichi ; Ando, Takao ; Ueki, Ikuko ; Horie, Ichiro ; Imaizumi, Misa ; Usa, Toshiro ; Abe, Kuniko ; Origuchi, Tomoki ; Eguchi, Katsumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-f20c483f246f397fcc86a46322f1d4cfeb29d9b2850ce3391bbf1782927e2be03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Diabetes insipidus</topic><topic>Diabetes Insipidus - complications</topic><topic>Diabetes Insipidus - diagnosis</topic><topic>Diabetes Insipidus - immunology</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Hypopituitarism</topic><topic>Hypopituitarism - complications</topic><topic>Hypopituitarism - diagnosis</topic><topic>Hypopituitarism - immunology</topic><topic>IgG4</topic><topic>Immunoglobulin G - blood</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Pituitary</topic><topic>Pituitary Hormones - blood</topic><topic>Prednisolone - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haraguchi, Ai</creatorcontrib><creatorcontrib>Era, Ai</creatorcontrib><creatorcontrib>Yasui, Junichi</creatorcontrib><creatorcontrib>Ando, Takao</creatorcontrib><creatorcontrib>Ueki, Ikuko</creatorcontrib><creatorcontrib>Horie, Ichiro</creatorcontrib><creatorcontrib>Imaizumi, Misa</creatorcontrib><creatorcontrib>Usa, Toshiro</creatorcontrib><creatorcontrib>Abe, Kuniko</creatorcontrib><creatorcontrib>Origuchi, Tomoki</creatorcontrib><creatorcontrib>Eguchi, Katsumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Endocrine Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haraguchi, Ai</au><au>Era, Ai</au><au>Yasui, Junichi</au><au>Ando, Takao</au><au>Ueki, Ikuko</au><au>Horie, Ichiro</au><au>Imaizumi, Misa</au><au>Usa, Toshiro</au><au>Abe, Kuniko</au><au>Origuchi, Tomoki</au><au>Eguchi, Katsumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Putative IgG4-related pituitary disease with hypopituitarism and/or diabetes insipidus accompanied with elevated serum levels of IgG4</atitle><jtitle>Endocrine Journal</jtitle><addtitle>Endocr J</addtitle><date>2010</date><risdate>2010</risdate><volume>57</volume><issue>8</issue><spage>719</spage><epage>725</epage><pages>719-725</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>IgG4-positive plasma cell infiltration into multiple organs or tissues, such as the pancreas and salivary glands, associated with increased serum levels of IgG4 is a characteristic finding seen in IgG4-related disease. Affected organs may appear tumorous as a result of chronic inflammatory processes accompanied with progressive fibrosis. Recent cases of this disorder in which the pituitary gland was affected include cases of diffuse enlargement of the pituitary and/or its stalk associated with central diabetes insipidus and/or impaired anterior hormone production. Here we report two such cases, as well as two additional previously undiagnosed cases found in our database. In order to make a correct diagnosis of pituitary lesion involvement with IgG4-related disease, the clinical background and concomitant disorders should be carefully taken into consideration and the measurement of serum levels of IgG4 seems to be useful.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>20467161</pmid><doi>10.1507/endocrj.K10E-030</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Aged Diabetes insipidus Diabetes Insipidus - complications Diabetes Insipidus - diagnosis Diabetes Insipidus - immunology Diagnosis, Differential Female Humans Hypopituitarism Hypopituitarism - complications Hypopituitarism - diagnosis Hypopituitarism - immunology IgG4 Immunoglobulin G - blood Magnetic Resonance Imaging Male Pituitary Pituitary Hormones - blood Prednisolone - therapeutic use |
| title | Putative IgG4-related pituitary disease with hypopituitarism and/or diabetes insipidus accompanied with elevated serum levels of IgG4 |
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