The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation

GM-CSF is an important cytokine involved in myeloid differentiation and inflammatory processes. Signaling through the GM-CSFR also plays a critical role in the generation of monocyte-derived dendritic cells (DC). In this article, we report that the Src-like adaptor protein (SLAP) functions as a nega...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-02, Vol.186 (4), p.1923-1933
Hauptverfasser:	Liontos, Larissa M, Dissanayake, Dilan, Ohashi, Pamela S, Weiss, Arthur, Dragone, Leonard L, McGlade, C Jane
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - physiology Animals Cell Differentiation - genetics Cell Differentiation - immunology Cytokine Receptor Common beta Subunit - antagonists & inhibitors Cytokine Receptor Common beta Subunit - metabolism Cytokine Receptor Common beta Subunit - physiology Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - pathology Down-Regulation - genetics Down-Regulation - immunology Growth Inhibitors - deficiency Growth Inhibitors - genetics Growth Inhibitors - physiology Mice Mice, Knockout Mice, Transgenic Monocytes - immunology Monocytes - metabolism Monocytes - pathology Proto-Oncogene Proteins pp60(c-src) - deficiency Proto-Oncogene Proteins pp60(c-src) - genetics Proto-Oncogene Proteins pp60(c-src) - physiology Signal Transduction - genetics Signal Transduction - immunology
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