Functional characteristics of the high affinity IgG receptor, FcγRI
IgG FcRs are important mediators of immunity and play a key role during Ab-based immunotherapy. Within the leukocyte IgG receptor family, only FcγRI is capable of IgG binding with high affinity. FcγRI exists as a complex of a ligand binding α-chain and an FcR γ-chain. The receptors' α-chain can...
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| Veröffentlicht in: | The Journal of immunology (1950) 2011-03, Vol.186 (5), p.2699-2704 |
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| container_issue | 5 |
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| container_title | The Journal of immunology (1950) |
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| creator | van der Poel, Cees E Spaapen, Robbert M van de Winkel, Jan G J Leusen, Jeanette H W |
| description | IgG FcRs are important mediators of immunity and play a key role during Ab-based immunotherapy. Within the leukocyte IgG receptor family, only FcγRI is capable of IgG binding with high affinity. FcγRI exists as a complex of a ligand binding α-chain and an FcR γ-chain. The receptors' α-chain can, furthermore, elicit several functions independent of the ITAM-bearing FcR γ-chain. Functional implications of high-affinity IgG binding and mechanisms underlying FcR γ-chain-independent signaling remain unclear to this day. In this paper, we provide an overview of past literature on FcγRI and address the implications of recently described interactions between cytosolic proteins and the FcγRI α-chain, as well as cytokine-enhanced FcγRI immune complex binding. Furthermore, an analysis of potential polymorphisms within the FCGR1A gene is provided. |
| doi_str_mv | 10.4049/jimmunol.1003526 |
| format | Article |
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| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Animals Antigen Presentation - genetics Antigen Presentation - immunology Antigen-Antibody Complex - chemistry Antigen-Antibody Complex - genetics Antigen-Antibody Complex - physiology Binding Sites, Antibody - genetics Disease Models, Animal Humans Molecular Sequence Data Protein Binding - genetics Protein Binding - immunology Protein Structure, Tertiary - genetics Receptors, IgG - chemistry Receptors, IgG - genetics Receptors, IgG - physiology |
| title | Functional characteristics of the high affinity IgG receptor, FcγRI |
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