Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1β secretion by activating the NLRP3 inflammasome
Clinical use of antibiotics is based on their capacity to inhibit bacterial growth via bacteriostatic or bacteriocidal effects. In this article, we show that the aminoglycoside antibiotic neomycin, the cyclic lipopeptide antibiotic polymyxin B, and the cyclic peptide antibiotics gramicidin and tyrot...
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| Veröffentlicht in: | The Journal of immunology (1950) 2011-03, Vol.186 (5), p.2714-2718 |
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| container_title | The Journal of immunology (1950) |
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| creator | Allam, Ramanjaneyulu Darisipudi, Murthy Narayana Rupanagudi, Khader Valli Lichtnekert, Julia Tschopp, Jurg Anders, Hans-Joachim |
| description | Clinical use of antibiotics is based on their capacity to inhibit bacterial growth via bacteriostatic or bacteriocidal effects. In this article, we show that the aminoglycoside antibiotic neomycin, the cyclic lipopeptide antibiotic polymyxin B, and the cyclic peptide antibiotics gramicidin and tyrothricin can induce IL-1β secretion in bone marrow dendritic cells and macrophages. LPS priming was required to trigger the transcription and translation of pro-IL-1β but was independent of TNFR or IL-1R signaling. All four antibiotics required the NLRP3 inflammasome, the adaptor ASC, and caspase-1 activation to secrete IL-1β, a process that depended on potassium efflux but was independent of P2X7 receptor. All four antibiotics induced neutrophil influx into the peritoneal cavity of mice, which required NLRP3 only in the case of polymyxin B. Together, certain antibiotics have the potential to directly activate innate immunity of the host. |
| doi_str_mv | 10.4049/jimmunol.1002657 |
| format | Article |
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In this article, we show that the aminoglycoside antibiotic neomycin, the cyclic lipopeptide antibiotic polymyxin B, and the cyclic peptide antibiotics gramicidin and tyrothricin can induce IL-1β secretion in bone marrow dendritic cells and macrophages. LPS priming was required to trigger the transcription and translation of pro-IL-1β but was independent of TNFR or IL-1R signaling. All four antibiotics required the NLRP3 inflammasome, the adaptor ASC, and caspase-1 activation to secrete IL-1β, a process that depended on potassium efflux but was independent of P2X7 receptor. All four antibiotics induced neutrophil influx into the peritoneal cavity of mice, which required NLRP3 only in the case of polymyxin B. 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In this article, we show that the aminoglycoside antibiotic neomycin, the cyclic lipopeptide antibiotic polymyxin B, and the cyclic peptide antibiotics gramicidin and tyrothricin can induce IL-1β secretion in bone marrow dendritic cells and macrophages. LPS priming was required to trigger the transcription and translation of pro-IL-1β but was independent of TNFR or IL-1R signaling. All four antibiotics required the NLRP3 inflammasome, the adaptor ASC, and caspase-1 activation to secrete IL-1β, a process that depended on potassium efflux but was independent of P2X7 receptor. All four antibiotics induced neutrophil influx into the peritoneal cavity of mice, which required NLRP3 only in the case of polymyxin B. Together, certain antibiotics have the potential to directly activate innate immunity of the host.</description><subject>Aminoglycosides - pharmacology</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bone Marrow Cells - drug effects</subject><subject>Bone Marrow Cells - immunology</subject><subject>Bone Marrow Cells - pathology</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - metabolism</subject><subject>Dendritic Cells - pathology</subject><subject>Humans</subject><subject>Inflammasomes - genetics</subject><subject>Inflammasomes - metabolism</subject><subject>Inflammasomes - physiology</subject><subject>Interleukin-1beta - biosynthesis</subject><subject>Interleukin-1beta - secretion</subject><subject>Macrophage Activation - drug effects</subject><subject>Macrophage Activation - immunology</subject><subject>Macrophages, Peritoneal - immunology</subject><subject>Macrophages, Peritoneal - metabolism</subject><subject>Macrophages, Peritoneal - pathology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>NLR Family, Pyrin Domain-Containing 3 Protein</subject><subject>Peptides, Cyclic - pharmacology</subject><subject>Peritonitis - immunology</subject><subject>Peritonitis - metabolism</subject><subject>Peritonitis - pathology</subject><subject>Protein Precursors - biosynthesis</subject><subject>Protein Precursors - secretion</subject><subject>Receptors, Interleukin-1 - deficiency</subject><subject>Receptors, Interleukin-1 - genetics</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1O3DAURq2qqEyH7rtC3nWVqf-dsKtG0CKNCkKwjhznJhjFcYidSlnwUjwIz9TQGbpldaVP9zvSvQehr5RsBBHF9wfn_dSHbkMJYUrqD2hFpSSZUkR9RKslZBnVSh-jzzE-EEIUYeITOmaU6ZwLsUJP2ykl17cY6hbOsJ1t5yweQjcPMCRXAzZ9jY13fWi72Ya4j5KrXEjORpxG17Yw4stdRl-ecQQ7QnKhx9WMjU3uj_mHT_eAf-9urjl2fdMZ700MHk7QUWO6CF8Oc43uLs5vt7-y3dXPy-2PXWa5ZikzUEkqgfE8r7g2uTaNtKKpmNI1y3llqSiMkBqUzmspiiI3y-mGcSULyqjga_Rtzx3G8DhBTKV30ULXmR7CFMuCaCqFUPTdzVyyYvk8f2WS_aYdQ4wjNOUwOm_GuaSkfLVTvtkpD3aWyukBPlUe6v-FNx38L8InjlE</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Allam, Ramanjaneyulu</creator><creator>Darisipudi, Murthy Narayana</creator><creator>Rupanagudi, Khader Valli</creator><creator>Lichtnekert, Julia</creator><creator>Tschopp, Jurg</creator><creator>Anders, Hans-Joachim</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20110301</creationdate><title>Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1β secretion by activating the NLRP3 inflammasome</title><author>Allam, Ramanjaneyulu ; Darisipudi, Murthy Narayana ; Rupanagudi, Khader Valli ; Lichtnekert, Julia ; Tschopp, Jurg ; Anders, Hans-Joachim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-aeb515e2388b37a87af5c4fb267d283bc149a457e678d54998a002a2365912143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aminoglycosides - pharmacology</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bone Marrow Cells - drug effects</topic><topic>Bone Marrow Cells - immunology</topic><topic>Bone Marrow Cells - pathology</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - metabolism</topic><topic>Dendritic Cells - immunology</topic><topic>Dendritic Cells - metabolism</topic><topic>Dendritic Cells - pathology</topic><topic>Humans</topic><topic>Inflammasomes - genetics</topic><topic>Inflammasomes - metabolism</topic><topic>Inflammasomes - physiology</topic><topic>Interleukin-1beta - biosynthesis</topic><topic>Interleukin-1beta - secretion</topic><topic>Macrophage Activation - drug effects</topic><topic>Macrophage Activation - immunology</topic><topic>Macrophages, Peritoneal - immunology</topic><topic>Macrophages, Peritoneal - metabolism</topic><topic>Macrophages, Peritoneal - pathology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>NLR Family, Pyrin Domain-Containing 3 Protein</topic><topic>Peptides, Cyclic - pharmacology</topic><topic>Peritonitis - immunology</topic><topic>Peritonitis - metabolism</topic><topic>Peritonitis - pathology</topic><topic>Protein Precursors - biosynthesis</topic><topic>Protein Precursors - secretion</topic><topic>Receptors, Interleukin-1 - deficiency</topic><topic>Receptors, Interleukin-1 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allam, Ramanjaneyulu</creatorcontrib><creatorcontrib>Darisipudi, Murthy Narayana</creatorcontrib><creatorcontrib>Rupanagudi, Khader Valli</creatorcontrib><creatorcontrib>Lichtnekert, Julia</creatorcontrib><creatorcontrib>Tschopp, Jurg</creatorcontrib><creatorcontrib>Anders, Hans-Joachim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allam, Ramanjaneyulu</au><au>Darisipudi, Murthy Narayana</au><au>Rupanagudi, Khader Valli</au><au>Lichtnekert, Julia</au><au>Tschopp, Jurg</au><au>Anders, Hans-Joachim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1β secretion by activating the NLRP3 inflammasome</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>186</volume><issue>5</issue><spage>2714</spage><epage>2718</epage><pages>2714-2718</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>Clinical use of antibiotics is based on their capacity to inhibit bacterial growth via bacteriostatic or bacteriocidal effects. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aminoglycosides - pharmacology Animals Anti-Bacterial Agents - pharmacology Bone Marrow Cells - drug effects Bone Marrow Cells - immunology Bone Marrow Cells - pathology Carrier Proteins - genetics Carrier Proteins - metabolism Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - pathology Humans Inflammasomes - genetics Inflammasomes - metabolism Inflammasomes - physiology Interleukin-1beta - biosynthesis Interleukin-1beta - secretion Macrophage Activation - drug effects Macrophage Activation - immunology Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Macrophages, Peritoneal - pathology Mice Mice, Inbred C57BL Mice, Knockout NLR Family, Pyrin Domain-Containing 3 Protein Peptides, Cyclic - pharmacology Peritonitis - immunology Peritonitis - metabolism Peritonitis - pathology Protein Precursors - biosynthesis Protein Precursors - secretion Receptors, Interleukin-1 - deficiency Receptors, Interleukin-1 - genetics |
| title | Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1β secretion by activating the NLRP3 inflammasome |
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