Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model

Psoriasis is an inflammatory disease with dynamic interactions between the immune system and the skin. The IL-23/Th17 axis plays an important role in the pathogenesis of psoriasis, although the exact contributions of IL-23 and IL-17 in vivo remain unclear. K5.Stat3C transgenic mice constitutively ex...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-04, Vol.186 (7), p.4481-4489
Hauptverfasser:	Nakajima, Kimiko, Kanda, Takashi, Takaishi, Mikiro, Shiga, Takeo, Miyoshi, Ken, Nakajima, Hideki, Kamijima, Reiko, Tarutani, Masahito, Benson, Jacqueline M, Elloso, M Merle, Gutshall, Lester L, Naso, Michael F, Iwakura, Yoichiro, DiGiovanni, John, Sano, Shigetoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Defensins - biosynthesis Cells, Cultured Cytokines - biosynthesis Disease Models, Animal Female Gene Expression Regulation - immunology Humans Immunization, Passive Immunophenotyping Interleukin-17 - immunology Interleukin-17 - physiology Interleukin-23 - immunology Interleukin-23 - physiology Killer Cells, Natural - immunology Killer Cells, Natural - pathology Male Mice Mice, Transgenic NIH 3T3 Cells Psoriasis - immunology Psoriasis - pathology Psoriasis - therapy S100 Proteins - biosynthesis T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - pathology Tetradecanoylphorbol Acetate - analogs & derivatives Tetradecanoylphorbol Acetate - toxicity
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