Dismal response to high-dose methylprednisolone after failure to respond to standard dose in patients with acute GVHD
Corticosteroids such as methylprednisolone (MP) remain the primary therapy for acute GVHD (aGVHD). Patients who are refractory to standard treatment (MP 2 mg/kg/day) may be treated with high-dose MP. This study evaluated the response to high-dose MP in children with aGVHD refractory to standard dose...
Gespeichert in:
| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2010-12, Vol.45 (12), p.1749-1753 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1753 |
|---|---|
| container_issue | 12 |
| container_start_page | 1749 |
| container_title | Bone marrow transplantation (Basingstoke) |
| container_volume | 45 |
| creator | Schechter, T Macartney, C Finkelstein, Y Gassas, A Husain, M Doyle, J Dupuis, L L |
| description | Corticosteroids such as methylprednisolone (MP) remain the primary therapy for acute GVHD (aGVHD). Patients who are refractory to standard treatment (MP 2 mg/kg/day) may be treated with high-dose MP. This study evaluated the response to high-dose MP in children with aGVHD refractory to standard dose MP. Children who underwent hematopoietic SCT (HSCT) at our hospital between 1 June 2002 and 31 July 2006 and were treated with high-dose MP upon developing steroid-refractory aGVHD were included. Response to aGVHD therapy, adverse effects attributed to MP and overall outcomes were documented. Ten children received high-dose MP (⩾20 mg/kg/day) on 3–5 consecutive days followed by a tapering dose for steroid-refractory aGVHD, at a median of 12 days after starting standard treatment. Nine patients had ⩾grade III aGVHD. Only one patient with grade III aGVHD had a complete response. Two patients had a partial response but flared when MP was tapered. Complications included hypertension (100%), hyperglycemia requiring insulin therapy (33%) and four documented severe infections. Five children (50%) died (median follow-up: 5.9 years). Salvage therapy other than high-dose MP should be considered in children who fail to respond to MP 2 mg/kg/day. |
| doi_str_mv | 10.1038/bmt.2010.47 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_907154171</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A245393316</galeid><sourcerecordid>A245393316</sourcerecordid><originalsourceid>FETCH-LOGICAL-c601t-a51022bb0068ac061a704abeb0e9f7cf45fd7f3cd0fd65b5655e51b9b7d26ff43</originalsourceid><addsrcrecordid>eNqF0ktv1DAUBlALgegwsGIPEQhYQAbb8SNZVi20SJXYAFvL8WPiKnGmtiPUf4_TDB2KilAWiZ1zbV37A-A5ghsEq_pjO6QNhnlE-AOwQoSzklaMPgQriFldVhVrjsCTGC8hRIRA-hgcYYhhTXm1AtOpi4Psi2DibvTRFGksOrftSj3mwWBSd93vgtHexbEfvSmkTSYUVrp-Cjd6qdTzZ0zSaxl0cVPsfLGTyRmfYvHTpa6QakqmOPtxfvoUPLKyj-bZ_r0G3z9_-nZyXl58PftycnxRKgZRKiVFEOO2hZDVUkGGJIdEtqaFprFcWUKt5rZSGlrNaEsZpYaitmm5xsxaUq3Bu2XdXRivJhOTGFxUpu-lN-MURQM5ogRx9F9ZY0Tqpq5n-eoveTlOwec2RI0Y4wjng12D1_9CmBGMKGWMHNRW9kY4b8cUpJo3FseY0KqpKsSy2tyj8qPN4FS-E-vy_J2Ct38UdEb2qcu3NyWXb_gufL9AFcYYg7FiF9wgw7VAUMzZEjlbYs6WIHNPL_Y9Te1g9K39HaYM3uyBjEr2NkivXDy4HEqEapzdh8XF_MtvTTgczv37vly4lyln7na9bGaSxS-Zmu2P</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2642155664</pqid></control><display><type>article</type><title>Dismal response to high-dose methylprednisolone after failure to respond to standard dose in patients with acute GVHD</title><source>MEDLINE</source><source>SpringerLink_现刊</source><source>Nature Journals Online</source><source>EZB Electronic Journals Library</source><creator>Schechter, T ; Macartney, C ; Finkelstein, Y ; Gassas, A ; Husain, M ; Doyle, J ; Dupuis, L L</creator><creatorcontrib>Schechter, T ; Macartney, C ; Finkelstein, Y ; Gassas, A ; Husain, M ; Doyle, J ; Dupuis, L L</creatorcontrib><description>Corticosteroids such as methylprednisolone (MP) remain the primary therapy for acute GVHD (aGVHD). Patients who are refractory to standard treatment (MP 2 mg/kg/day) may be treated with high-dose MP. This study evaluated the response to high-dose MP in children with aGVHD refractory to standard dose MP. Children who underwent hematopoietic SCT (HSCT) at our hospital between 1 June 2002 and 31 July 2006 and were treated with high-dose MP upon developing steroid-refractory aGVHD were included. Response to aGVHD therapy, adverse effects attributed to MP and overall outcomes were documented. Ten children received high-dose MP (⩾20 mg/kg/day) on 3–5 consecutive days followed by a tapering dose for steroid-refractory aGVHD, at a median of 12 days after starting standard treatment. Nine patients had ⩾grade III aGVHD. Only one patient with grade III aGVHD had a complete response. Two patients had a partial response but flared when MP was tapered. Complications included hypertension (100%), hyperglycemia requiring insulin therapy (33%) and four documented severe infections. Five children (50%) died (median follow-up: 5.9 years). Salvage therapy other than high-dose MP should be considered in children who fail to respond to MP 2 mg/kg/day.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/bmt.2010.47</identifier><identifier>PMID: 20208573</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/92/436/108 ; 692/699/249/1529 ; Acute Disease ; Adolescent ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone marrow ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Care and treatment ; Cell Biology ; Child ; Child, Preschool ; Children ; Complications ; Complications and side effects ; Corticoids ; Corticosteroids ; Development and progression ; Dosage and administration ; Dose-Response Relationship, Drug ; Female ; Glucocorticoids - administration & dosage ; Graft versus host reaction ; Graft vs Host Disease - drug therapy ; Health aspects ; Hematology ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Hyperglycemia ; Hypertension ; Infant ; Infant, Newborn ; Insulin ; Internal Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Methylprednisolone ; Methylprednisolone - administration & dosage ; original-article ; Patient outcomes ; Patients ; Political aspects ; Public Health ; Risk factors ; Stem cell transplantation ; Stem Cells ; Steroids ; Tapering ; Therapy ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>Bone marrow transplantation (Basingstoke), 2010-12, Vol.45 (12), p.1749-1753</ispartof><rights>Macmillan Publishers Limited 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Macmillan Publishers Limited 2010.</rights><rights>Copyright Nature Publishing Group Dec 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c601t-a51022bb0068ac061a704abeb0e9f7cf45fd7f3cd0fd65b5655e51b9b7d26ff43</citedby><cites>FETCH-LOGICAL-c601t-a51022bb0068ac061a704abeb0e9f7cf45fd7f3cd0fd65b5655e51b9b7d26ff43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/bmt.2010.47$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/bmt.2010.47$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23651182$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20208573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schechter, T</creatorcontrib><creatorcontrib>Macartney, C</creatorcontrib><creatorcontrib>Finkelstein, Y</creatorcontrib><creatorcontrib>Gassas, A</creatorcontrib><creatorcontrib>Husain, M</creatorcontrib><creatorcontrib>Doyle, J</creatorcontrib><creatorcontrib>Dupuis, L L</creatorcontrib><title>Dismal response to high-dose methylprednisolone after failure to respond to standard dose in patients with acute GVHD</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><addtitle>Bone Marrow Transplant</addtitle><description>Corticosteroids such as methylprednisolone (MP) remain the primary therapy for acute GVHD (aGVHD). Patients who are refractory to standard treatment (MP 2 mg/kg/day) may be treated with high-dose MP. This study evaluated the response to high-dose MP in children with aGVHD refractory to standard dose MP. Children who underwent hematopoietic SCT (HSCT) at our hospital between 1 June 2002 and 31 July 2006 and were treated with high-dose MP upon developing steroid-refractory aGVHD were included. Response to aGVHD therapy, adverse effects attributed to MP and overall outcomes were documented. Ten children received high-dose MP (⩾20 mg/kg/day) on 3–5 consecutive days followed by a tapering dose for steroid-refractory aGVHD, at a median of 12 days after starting standard treatment. Nine patients had ⩾grade III aGVHD. Only one patient with grade III aGVHD had a complete response. Two patients had a partial response but flared when MP was tapered. Complications included hypertension (100%), hyperglycemia requiring insulin therapy (33%) and four documented severe infections. Five children (50%) died (median follow-up: 5.9 years). Salvage therapy other than high-dose MP should be considered in children who fail to respond to MP 2 mg/kg/day.</description><subject>631/92/436/108</subject><subject>692/699/249/1529</subject><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Care and treatment</subject><subject>Cell Biology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Complications</subject><subject>Complications and side effects</subject><subject>Corticoids</subject><subject>Corticosteroids</subject><subject>Development and progression</subject><subject>Dosage and administration</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Graft versus host reaction</subject><subject>Graft vs Host Disease - drug therapy</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hypertension</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Insulin</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methylprednisolone</subject><subject>Methylprednisolone - administration & dosage</subject><subject>original-article</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Political aspects</subject><subject>Public Health</subject><subject>Risk factors</subject><subject>Stem cell transplantation</subject><subject>Stem Cells</subject><subject>Steroids</subject><subject>Tapering</subject><subject>Therapy</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>0268-3369</issn><issn>1476-5365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0ktv1DAUBlALgegwsGIPEQhYQAbb8SNZVi20SJXYAFvL8WPiKnGmtiPUf4_TDB2KilAWiZ1zbV37A-A5ghsEq_pjO6QNhnlE-AOwQoSzklaMPgQriFldVhVrjsCTGC8hRIRA-hgcYYhhTXm1AtOpi4Psi2DibvTRFGksOrftSj3mwWBSd93vgtHexbEfvSmkTSYUVrp-Cjd6qdTzZ0zSaxl0cVPsfLGTyRmfYvHTpa6QakqmOPtxfvoUPLKyj-bZ_r0G3z9_-nZyXl58PftycnxRKgZRKiVFEOO2hZDVUkGGJIdEtqaFprFcWUKt5rZSGlrNaEsZpYaitmm5xsxaUq3Bu2XdXRivJhOTGFxUpu-lN-MURQM5ogRx9F9ZY0Tqpq5n-eoveTlOwec2RI0Y4wjng12D1_9CmBGMKGWMHNRW9kY4b8cUpJo3FseY0KqpKsSy2tyj8qPN4FS-E-vy_J2Ct38UdEb2qcu3NyWXb_gufL9AFcYYg7FiF9wgw7VAUMzZEjlbYs6WIHNPL_Y9Te1g9K39HaYM3uyBjEr2NkivXDy4HEqEapzdh8XF_MtvTTgczv37vly4lyln7na9bGaSxS-Zmu2P</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Schechter, T</creator><creator>Macartney, C</creator><creator>Finkelstein, Y</creator><creator>Gassas, A</creator><creator>Husain, M</creator><creator>Doyle, J</creator><creator>Dupuis, L L</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20101201</creationdate><title>Dismal response to high-dose methylprednisolone after failure to respond to standard dose in patients with acute GVHD</title><author>Schechter, T ; Macartney, C ; Finkelstein, Y ; Gassas, A ; Husain, M ; Doyle, J ; Dupuis, L L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c601t-a51022bb0068ac061a704abeb0e9f7cf45fd7f3cd0fd65b5655e51b9b7d26ff43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>631/92/436/108</topic><topic>692/699/249/1529</topic><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Care and treatment</topic><topic>Cell Biology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Complications</topic><topic>Complications and side effects</topic><topic>Corticoids</topic><topic>Corticosteroids</topic><topic>Development and progression</topic><topic>Dosage and administration</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Graft versus host reaction</topic><topic>Graft vs Host Disease - drug therapy</topic><topic>Health aspects</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hypertension</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Insulin</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methylprednisolone</topic><topic>Methylprednisolone - administration & dosage</topic><topic>original-article</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Political aspects</topic><topic>Public Health</topic><topic>Risk factors</topic><topic>Stem cell transplantation</topic><topic>Stem Cells</topic><topic>Steroids</topic><topic>Tapering</topic><topic>Therapy</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schechter, T</creatorcontrib><creatorcontrib>Macartney, C</creatorcontrib><creatorcontrib>Finkelstein, Y</creatorcontrib><creatorcontrib>Gassas, A</creatorcontrib><creatorcontrib>Husain, M</creatorcontrib><creatorcontrib>Doyle, J</creatorcontrib><creatorcontrib>Dupuis, L L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Academic</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Bone marrow transplantation (Basingstoke)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schechter, T</au><au>Macartney, C</au><au>Finkelstein, Y</au><au>Gassas, A</au><au>Husain, M</au><au>Doyle, J</au><au>Dupuis, L L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dismal response to high-dose methylprednisolone after failure to respond to standard dose in patients with acute GVHD</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><stitle>Bone Marrow Transplant</stitle><addtitle>Bone Marrow Transplant</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>45</volume><issue>12</issue><spage>1749</spage><epage>1753</epage><pages>1749-1753</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><coden>BMTRE9</coden><abstract>Corticosteroids such as methylprednisolone (MP) remain the primary therapy for acute GVHD (aGVHD). Patients who are refractory to standard treatment (MP 2 mg/kg/day) may be treated with high-dose MP. This study evaluated the response to high-dose MP in children with aGVHD refractory to standard dose MP. Children who underwent hematopoietic SCT (HSCT) at our hospital between 1 June 2002 and 31 July 2006 and were treated with high-dose MP upon developing steroid-refractory aGVHD were included. Response to aGVHD therapy, adverse effects attributed to MP and overall outcomes were documented. Ten children received high-dose MP (⩾20 mg/kg/day) on 3–5 consecutive days followed by a tapering dose for steroid-refractory aGVHD, at a median of 12 days after starting standard treatment. Nine patients had ⩾grade III aGVHD. Only one patient with grade III aGVHD had a complete response. Two patients had a partial response but flared when MP was tapered. Complications included hypertension (100%), hyperglycemia requiring insulin therapy (33%) and four documented severe infections. Five children (50%) died (median follow-up: 5.9 years). Salvage therapy other than high-dose MP should be considered in children who fail to respond to MP 2 mg/kg/day.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20208573</pmid><doi>10.1038/bmt.2010.47</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2010-12, Vol.45 (12), p.1749-1753 |
| issn | 0268-3369 1476-5365 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_907154171 |
| source | MEDLINE; SpringerLink_现刊; Nature Journals Online; EZB Electronic Journals Library |
| subjects | 631/92/436/108 692/699/249/1529 Acute Disease Adolescent Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Care and treatment Cell Biology Child Child, Preschool Children Complications Complications and side effects Corticoids Corticosteroids Development and progression Dosage and administration Dose-Response Relationship, Drug Female Glucocorticoids - administration & dosage Graft versus host reaction Graft vs Host Disease - drug therapy Health aspects Hematology Hematopoietic Stem Cell Transplantation - adverse effects Humans Hyperglycemia Hypertension Infant Infant, Newborn Insulin Internal Medicine Male Medical sciences Medicine Medicine & Public Health Methylprednisolone Methylprednisolone - administration & dosage original-article Patient outcomes Patients Political aspects Public Health Risk factors Stem cell transplantation Stem Cells Steroids Tapering Therapy Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Dismal response to high-dose methylprednisolone after failure to respond to standard dose in patients with acute GVHD |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T14%3A18%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dismal%20response%20to%20high-dose%20methylprednisolone%20after%20failure%20to%20respond%20to%20standard%20dose%20in%20patients%20with%20acute%20GVHD&rft.jtitle=Bone%20marrow%20transplantation%20(Basingstoke)&rft.au=Schechter,%20T&rft.date=2010-12-01&rft.volume=45&rft.issue=12&rft.spage=1749&rft.epage=1753&rft.pages=1749-1753&rft.issn=0268-3369&rft.eissn=1476-5365&rft.coden=BMTRE9&rft_id=info:doi/10.1038/bmt.2010.47&rft_dat=%3Cgale_proqu%3EA245393316%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2642155664&rft_id=info:pmid/20208573&rft_galeid=A245393316&rfr_iscdi=true |