Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

Inflammation and oxidative stress are thought to promote tissue damage in multiple sclerosis. Thus, novel therapeutics enhancing cellular resistance to free radicals could prove useful for multiple sclerosis treatment. BG00012 is an oral formulation of dimethylfumarate. In a phase II multiple sclero...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2011-03, Vol.134 (Pt 3), p.678-692
Hauptverfasser:	Linker, Ralf A, Lee, De-Hyung, Ryan, Sarah, van Dam, Anne M, Conrad, Rebecca, Bista, Pradeep, Zeng, Weike, Hronowsky, Xiaoping, Buko, Alex, Chollate, Sowmya, Ellrichmann, Gisa, Brück, Wolfgang, Dawson, Kate, Goelz, Susan, Wiese, Stefan, Scannevin, Robert H, Lukashev, Matvey, Gold, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism Aldehyde Reductase - metabolism Animals Antigens, Differentiation - metabolism Antioxidants - metabolism Astrocytes - drug effects Astrocytes - immunology Axons - metabolism Axons - pathology CD3 Complex - metabolism Cell Proliferation - drug effects Cells, Cultured Chromatography, High Pressure Liquid - methods Cytokines - metabolism Disease Models, Animal Embryo, Mammalian Encephalomyelitis, Autoimmune, Experimental - etiology Encephalomyelitis, Autoimmune, Experimental - prevention & control Female Fumarates - pharmacology Fumarates - therapeutic use Gene Expression Regulation - drug effects Glycoproteins - adverse effects Green Fluorescent Proteins - genetics Humans Hydrogen Peroxide - pharmacology Mass Spectrometry Mice Mice, Inbred C57BL Motor Neurons - cytology Motor Neurons - drug effects Motor Neurons - metabolism Multiple Sclerosis - metabolism Multiple Sclerosis - pathology Myelin Proteins - metabolism Myelin-Oligodendrocyte Glycoprotein NAD(P)H Dehydrogenase (Quinone) - metabolism Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use NF-E2-Related Factor 2 - metabolism Nogo Proteins Oxidative Stress - drug effects Peptide Fragments - adverse effects RNA, Small Interfering - pharmacology Signal Transduction - drug effects Sleep - physiology Spinal Cord - cytology Statistics, Nonparametric Tandem Mass Spectrometry - methods Time Factors Transfection
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