Gamma oscillations in the hippocampus require high complex I gene expression and strong functional performance of mitochondria

Fast neuronal network oscillations in the gamma range (~30-90 Hz) have been implicated in complex brain functions such as sensory processing, memory formation and, perhaps, consciousness, and appear to be exceptionally vulnerable to various pathologies. However, both energy demand and mitochondrial...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2011-02, Vol.134 (Pt 2), p.345-358
Hauptverfasser:	KANN, Oliver, HUCHZERMEYER, Christine, KOVACS, Richard, WIRTZ, Stefanie, SCHUELKE, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Biological and medical sciences Brain Waves - drug effects Brain Waves - genetics Brain Waves - physiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Electron Transport Complex I - antagonists & inhibitors Electron Transport Complex I - biosynthesis Gene Expression - drug effects Gene Expression - physiology Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiology In Vitro Techniques Medical sciences Mice Mice, Inbred C57BL Mitochondria - genetics Mitochondria - metabolism Neurology Oxidation-Reduction Oxygen Consumption - drug effects Oxygen Consumption - physiology Rats Rats, Wistar
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