Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine

Background Cognitive deficits are a core feature of schizophrenia that respond minimally to existing drugs. PCP is commonly used to model schizophrenia-like deficits preclinically although different dosing protocols may affect different domains. Here we characterise the acute, and chronic intermitte...

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Veröffentlicht in:	Psychopharmacologia 2011-02, Vol.213 (4), p.681-695
Hauptverfasser:	Thomson, David M., McVie, Allan, Morris, Brian J., Pratt, Judith A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Antipsychotic Agents - administration & dosage Antipsychotic Agents - pharmacology Attention Attention - drug effects Biological and medical sciences Biomedical and Life Sciences Biomedicine Choice Behavior - drug effects Clozapine Clozapine - administration & dosage Clozapine - pharmacology Cognition & reasoning Cognition Disorders - chemically induced Cognition Disorders - drug therapy Cognitive ability Disease Models, Animal Drug Administration Schedule Drugs GABA Antagonists - administration & dosage GABA Antagonists - pharmacology Glutamic acid receptors (ionotropic) Information processing Male Medical sciences Mental disorders Miscellaneous N-Methyl-D-aspartic acid receptors Neuropharmacology Neuropsychology Neurosciences Original Investigation Pharmacology. Drug treatments Pharmacology/Toxicology Phencyclidine - administration & dosage Phencyclidine - toxicity Psychiatry Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychotropic drugs Rats Rats, Long-Evans Reaction Time - drug effects Reaction time task Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Response time Schizophrenia Signal Detection, Psychological Time Factors Translation
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