Maternal food consumption during pregnancy and risk of advanced β-cell autoimmunity in the offspring
Virtanen SM, Uusitalo L, Kenward MG, Nevalainen J, Uusitalo U, Kronberg‐Kippilä C, Ovaskainen M‐L, Arkkola T, Niinistö S, Hakulinen T, Ahonen S, Simell O, Ilonen J, Veijola R, Knip M. Maternal food consumption during pregnancy and risk of advanced β‐cell autoimmunity in the offspring. Background: Ev...
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| Veröffentlicht in: | Pediatric diabetes 2011-03, Vol.12 (2), p.95-99 |
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| creator | Virtanen, SM Uusitalo, L Kenward, MG Nevalainen, J Uusitalo, U Kronberg-Kippilä, C Ovaskainen, M-L Arkkola, T Niinistö, S Hakulinen, T Ahonen, S Simell, O Ilonen, J Veijola, R Knip, M |
| description | Virtanen SM, Uusitalo L, Kenward MG, Nevalainen J, Uusitalo U, Kronberg‐Kippilä C, Ovaskainen M‐L, Arkkola T, Niinistö S, Hakulinen T, Ahonen S, Simell O, Ilonen J, Veijola R, Knip M. Maternal food consumption during pregnancy and risk of advanced β‐cell autoimmunity in the offspring.
Background: Evidence for a putative role of maternal diet during pregnancy in the development of β‐cell autoimmunity in the child is scarce. The authors study the association of food consumption during pregnancy and the development of β‐cell autoimmunity in the offspring.
Subjects and methods: A prospective Finnish birth cohort of 4297 infants with human leukocyte antigen (HLA)‐DQB1‐conferred susceptibility to type 1 diabetes and their mothers. Blood samples were collected from the children at 3–12 months intervals to measure type 1 diabetes‐associated antibodies: antibodies against islet cells (ICA), insulin, glutamate dehydroxylase, and islet antigen 2. The mothers completed a validated food frequency questionnaire. The end‐point was repeated positivity for ICA together with at least one of the other three antibodies. Piecewise‐exponential survival models were used. The effective sample size was 3723, with 138 end‐points. The median follow‐up time was 4.4 years.
Results: Maternal consumption of butter, low‐fat margarines, berries, and coffee were inversely associated with the development of advanced β‐cell autoimmunity in the offspring, adjusted for genetic risk group and familial diabetes. These associations for low‐fat margarines (use vs. non‐use HR 0.60, 95% CI: 0.38–0.93, p = 0.02), berries (continuous variable HR 0.90, 95% CI: 0.83–0.98, p = 0.02) and coffee (highest quarter vs. lowest HR 0.62, 95% CI: 0.40–0.97, p = 0.04), remained significant when adjusting for potential confounding sociodemographic, perinatal, and other dietary factors.
Conclusions: In this study assessing total food consumption of the mother during pregnancy, only few among the 27 food groups tested were weakly related to the development of advanced β‐cell autoimmunity in Finnish children. |
| doi_str_mv | 10.1111/j.1399-5448.2010.00668.x |
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Background: Evidence for a putative role of maternal diet during pregnancy in the development of β‐cell autoimmunity in the child is scarce. The authors study the association of food consumption during pregnancy and the development of β‐cell autoimmunity in the offspring.
Subjects and methods: A prospective Finnish birth cohort of 4297 infants with human leukocyte antigen (HLA)‐DQB1‐conferred susceptibility to type 1 diabetes and their mothers. Blood samples were collected from the children at 3–12 months intervals to measure type 1 diabetes‐associated antibodies: antibodies against islet cells (ICA), insulin, glutamate dehydroxylase, and islet antigen 2. The mothers completed a validated food frequency questionnaire. The end‐point was repeated positivity for ICA together with at least one of the other three antibodies. Piecewise‐exponential survival models were used. The effective sample size was 3723, with 138 end‐points. The median follow‐up time was 4.4 years.
Results: Maternal consumption of butter, low‐fat margarines, berries, and coffee were inversely associated with the development of advanced β‐cell autoimmunity in the offspring, adjusted for genetic risk group and familial diabetes. These associations for low‐fat margarines (use vs. non‐use HR 0.60, 95% CI: 0.38–0.93, p = 0.02), berries (continuous variable HR 0.90, 95% CI: 0.83–0.98, p = 0.02) and coffee (highest quarter vs. lowest HR 0.62, 95% CI: 0.40–0.97, p = 0.04), remained significant when adjusting for potential confounding sociodemographic, perinatal, and other dietary factors.
Conclusions: In this study assessing total food consumption of the mother during pregnancy, only few among the 27 food groups tested were weakly related to the development of advanced β‐cell autoimmunity in Finnish children.</description><identifier>ISSN: 1399-543X</identifier><identifier>EISSN: 1399-5448</identifier><identifier>DOI: 10.1111/j.1399-5448.2010.00668.x</identifier><identifier>PMID: 21352426</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Antibodies ; autoantibodies ; Autoantibodies - analysis ; Autoantibodies - blood ; Autoimmunity ; Autoimmunity - physiology ; Beta cells ; Butter ; Children ; Coffee ; Diabetes mellitus ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - epidemiology ; Diabetes Mellitus, Type 1 - etiology ; Diabetes Mellitus, Type 1 - immunology ; Diets ; Disease Progression ; Eating - physiology ; epidemiology ; Female ; food ; Food consumption ; Fruit ; Fruits ; Glutamic acid ; Histocompatibility antigen HLA ; Humans ; Infant, Newborn ; Infants ; Insulin ; Insulin-Secreting Cells - immunology ; Inventories ; Islet cells ; Islets of Langerhans ; Margarine ; Maternal Nutritional Physiological Phenomena ; Nutrition Surveys ; Pregnancy ; Prenatal Exposure Delayed Effects - blood ; Prenatal Exposure Delayed Effects - epidemiology ; Prenatal Exposure Delayed Effects - immunology ; Progeny ; Risk Factors ; Risk groups ; type 1</subject><ispartof>Pediatric diabetes, 2011-03, Vol.12 (2), p.95-99</ispartof><rights>2010 John Wiley & Sons A/S</rights><rights>2010 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4888-7358c5f82ffb605e657b2bc459432c03eba26e4e7598c616867284866d182abf3</citedby><cites>FETCH-LOGICAL-c4888-7358c5f82ffb605e657b2bc459432c03eba26e4e7598c616867284866d182abf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-5448.2010.00668.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-5448.2010.00668.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21352426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Virtanen, SM</creatorcontrib><creatorcontrib>Uusitalo, L</creatorcontrib><creatorcontrib>Kenward, MG</creatorcontrib><creatorcontrib>Nevalainen, J</creatorcontrib><creatorcontrib>Uusitalo, U</creatorcontrib><creatorcontrib>Kronberg-Kippilä, C</creatorcontrib><creatorcontrib>Ovaskainen, M-L</creatorcontrib><creatorcontrib>Arkkola, T</creatorcontrib><creatorcontrib>Niinistö, S</creatorcontrib><creatorcontrib>Hakulinen, T</creatorcontrib><creatorcontrib>Ahonen, S</creatorcontrib><creatorcontrib>Simell, O</creatorcontrib><creatorcontrib>Ilonen, J</creatorcontrib><creatorcontrib>Veijola, R</creatorcontrib><creatorcontrib>Knip, M</creatorcontrib><title>Maternal food consumption during pregnancy and risk of advanced β-cell autoimmunity in the offspring</title><title>Pediatric diabetes</title><addtitle>Pediatr Diabetes</addtitle><description>Virtanen SM, Uusitalo L, Kenward MG, Nevalainen J, Uusitalo U, Kronberg‐Kippilä C, Ovaskainen M‐L, Arkkola T, Niinistö S, Hakulinen T, Ahonen S, Simell O, Ilonen J, Veijola R, Knip M. Maternal food consumption during pregnancy and risk of advanced β‐cell autoimmunity in the offspring.
Background: Evidence for a putative role of maternal diet during pregnancy in the development of β‐cell autoimmunity in the child is scarce. The authors study the association of food consumption during pregnancy and the development of β‐cell autoimmunity in the offspring.
Subjects and methods: A prospective Finnish birth cohort of 4297 infants with human leukocyte antigen (HLA)‐DQB1‐conferred susceptibility to type 1 diabetes and their mothers. Blood samples were collected from the children at 3–12 months intervals to measure type 1 diabetes‐associated antibodies: antibodies against islet cells (ICA), insulin, glutamate dehydroxylase, and islet antigen 2. The mothers completed a validated food frequency questionnaire. The end‐point was repeated positivity for ICA together with at least one of the other three antibodies. Piecewise‐exponential survival models were used. The effective sample size was 3723, with 138 end‐points. The median follow‐up time was 4.4 years.
Results: Maternal consumption of butter, low‐fat margarines, berries, and coffee were inversely associated with the development of advanced β‐cell autoimmunity in the offspring, adjusted for genetic risk group and familial diabetes. These associations for low‐fat margarines (use vs. non‐use HR 0.60, 95% CI: 0.38–0.93, p = 0.02), berries (continuous variable HR 0.90, 95% CI: 0.83–0.98, p = 0.02) and coffee (highest quarter vs. lowest HR 0.62, 95% CI: 0.40–0.97, p = 0.04), remained significant when adjusting for potential confounding sociodemographic, perinatal, and other dietary factors.
Conclusions: In this study assessing total food consumption of the mother during pregnancy, only few among the 27 food groups tested were weakly related to the development of advanced β‐cell autoimmunity in Finnish children.</description><subject>Antibodies</subject><subject>autoantibodies</subject><subject>Autoantibodies - analysis</subject><subject>Autoantibodies - blood</subject><subject>Autoimmunity</subject><subject>Autoimmunity - physiology</subject><subject>Beta cells</subject><subject>Butter</subject><subject>Children</subject><subject>Coffee</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - epidemiology</subject><subject>Diabetes Mellitus, Type 1 - etiology</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diets</subject><subject>Disease Progression</subject><subject>Eating - physiology</subject><subject>epidemiology</subject><subject>Female</subject><subject>food</subject><subject>Food consumption</subject><subject>Fruit</subject><subject>Fruits</subject><subject>Glutamic acid</subject><subject>Histocompatibility antigen HLA</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Insulin</subject><subject>Insulin-Secreting Cells - immunology</subject><subject>Inventories</subject><subject>Islet cells</subject><subject>Islets of Langerhans</subject><subject>Margarine</subject><subject>Maternal Nutritional Physiological Phenomena</subject><subject>Nutrition Surveys</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - blood</subject><subject>Prenatal Exposure Delayed Effects - epidemiology</subject><subject>Prenatal Exposure Delayed Effects - immunology</subject><subject>Progeny</subject><subject>Risk Factors</subject><subject>Risk groups</subject><subject>type 1</subject><issn>1399-543X</issn><issn>1399-5448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1DAUhi0Eohd4BeQdq0x9t7NggUppq7ZcJBCoG8tJ7OJpYk_thM68Fg_CM9VhymzBGx8df_9v-z8AQIwWuKyj5QLTuq44Y2pBUOkiJIRarJ-A_d3B011Nv--Bg5yXCGFZU_Yc7BFMOWFE7AN7ZUabgumhi7GDbQx5GlajjwF2U_LhBq6SvQkmtBtoQgeTz7cwOmi6n6VnO_j7V9XavodmGqMfhin4cQN9gOMPWziXV7PJC_DMmT7bl4_7Ifj6_uTL8Vl1-fH0_PjtZdUypVQlKVctd4o41wjEreCyIU3LeM0oaRG1jSHCMit5rVqBhRKSKKaE6LAipnH0ELze-q5SvJtsHvXg8_w8E2ycsq6RxBxJRv5JKoFwLWqKCqm2ZJtizsk6Xb40mLTRGOl5Gnqp56D1HLqep6H_TEOvi_TV4yVTM9huJ_wbfwHebIF739vNfxvrTyfvzktV9NVW7_No1zu9SbdaSCq5_vbhVF9_VtcXNb_Qkj4A7aqo2Q</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Virtanen, SM</creator><creator>Uusitalo, L</creator><creator>Kenward, MG</creator><creator>Nevalainen, J</creator><creator>Uusitalo, U</creator><creator>Kronberg-Kippilä, C</creator><creator>Ovaskainen, M-L</creator><creator>Arkkola, T</creator><creator>Niinistö, S</creator><creator>Hakulinen, T</creator><creator>Ahonen, S</creator><creator>Simell, O</creator><creator>Ilonen, J</creator><creator>Veijola, R</creator><creator>Knip, M</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201103</creationdate><title>Maternal food consumption during pregnancy and risk of advanced β-cell autoimmunity in the offspring</title><author>Virtanen, SM ; Uusitalo, L ; Kenward, MG ; Nevalainen, J ; Uusitalo, U ; Kronberg-Kippilä, C ; Ovaskainen, M-L ; Arkkola, T ; Niinistö, S ; Hakulinen, T ; Ahonen, S ; Simell, O ; Ilonen, J ; Veijola, R ; Knip, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4888-7358c5f82ffb605e657b2bc459432c03eba26e4e7598c616867284866d182abf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Antibodies</topic><topic>autoantibodies</topic><topic>Autoantibodies - analysis</topic><topic>Autoantibodies - blood</topic><topic>Autoimmunity</topic><topic>Autoimmunity - physiology</topic><topic>Beta cells</topic><topic>Butter</topic><topic>Children</topic><topic>Coffee</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - epidemiology</topic><topic>Diabetes Mellitus, Type 1 - etiology</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Diets</topic><topic>Disease Progression</topic><topic>Eating - physiology</topic><topic>epidemiology</topic><topic>Female</topic><topic>food</topic><topic>Food consumption</topic><topic>Fruit</topic><topic>Fruits</topic><topic>Glutamic acid</topic><topic>Histocompatibility antigen HLA</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Insulin</topic><topic>Insulin-Secreting Cells - immunology</topic><topic>Inventories</topic><topic>Islet cells</topic><topic>Islets of Langerhans</topic><topic>Margarine</topic><topic>Maternal Nutritional Physiological Phenomena</topic><topic>Nutrition Surveys</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - blood</topic><topic>Prenatal Exposure Delayed Effects - epidemiology</topic><topic>Prenatal Exposure Delayed Effects - immunology</topic><topic>Progeny</topic><topic>Risk Factors</topic><topic>Risk groups</topic><topic>type 1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Virtanen, SM</creatorcontrib><creatorcontrib>Uusitalo, L</creatorcontrib><creatorcontrib>Kenward, MG</creatorcontrib><creatorcontrib>Nevalainen, J</creatorcontrib><creatorcontrib>Uusitalo, U</creatorcontrib><creatorcontrib>Kronberg-Kippilä, C</creatorcontrib><creatorcontrib>Ovaskainen, M-L</creatorcontrib><creatorcontrib>Arkkola, T</creatorcontrib><creatorcontrib>Niinistö, S</creatorcontrib><creatorcontrib>Hakulinen, T</creatorcontrib><creatorcontrib>Ahonen, S</creatorcontrib><creatorcontrib>Simell, O</creatorcontrib><creatorcontrib>Ilonen, J</creatorcontrib><creatorcontrib>Veijola, R</creatorcontrib><creatorcontrib>Knip, M</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Pediatric diabetes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Virtanen, SM</au><au>Uusitalo, L</au><au>Kenward, MG</au><au>Nevalainen, J</au><au>Uusitalo, U</au><au>Kronberg-Kippilä, C</au><au>Ovaskainen, M-L</au><au>Arkkola, T</au><au>Niinistö, S</au><au>Hakulinen, T</au><au>Ahonen, S</au><au>Simell, O</au><au>Ilonen, J</au><au>Veijola, R</au><au>Knip, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal food consumption during pregnancy and risk of advanced β-cell autoimmunity in the offspring</atitle><jtitle>Pediatric diabetes</jtitle><addtitle>Pediatr Diabetes</addtitle><date>2011-03</date><risdate>2011</risdate><volume>12</volume><issue>2</issue><spage>95</spage><epage>99</epage><pages>95-99</pages><issn>1399-543X</issn><eissn>1399-5448</eissn><abstract>Virtanen SM, Uusitalo L, Kenward MG, Nevalainen J, Uusitalo U, Kronberg‐Kippilä C, Ovaskainen M‐L, Arkkola T, Niinistö S, Hakulinen T, Ahonen S, Simell O, Ilonen J, Veijola R, Knip M. Maternal food consumption during pregnancy and risk of advanced β‐cell autoimmunity in the offspring.
Background: Evidence for a putative role of maternal diet during pregnancy in the development of β‐cell autoimmunity in the child is scarce. The authors study the association of food consumption during pregnancy and the development of β‐cell autoimmunity in the offspring.
Subjects and methods: A prospective Finnish birth cohort of 4297 infants with human leukocyte antigen (HLA)‐DQB1‐conferred susceptibility to type 1 diabetes and their mothers. Blood samples were collected from the children at 3–12 months intervals to measure type 1 diabetes‐associated antibodies: antibodies against islet cells (ICA), insulin, glutamate dehydroxylase, and islet antigen 2. The mothers completed a validated food frequency questionnaire. The end‐point was repeated positivity for ICA together with at least one of the other three antibodies. Piecewise‐exponential survival models were used. The effective sample size was 3723, with 138 end‐points. The median follow‐up time was 4.4 years.
Results: Maternal consumption of butter, low‐fat margarines, berries, and coffee were inversely associated with the development of advanced β‐cell autoimmunity in the offspring, adjusted for genetic risk group and familial diabetes. These associations for low‐fat margarines (use vs. non‐use HR 0.60, 95% CI: 0.38–0.93, p = 0.02), berries (continuous variable HR 0.90, 95% CI: 0.83–0.98, p = 0.02) and coffee (highest quarter vs. lowest HR 0.62, 95% CI: 0.40–0.97, p = 0.04), remained significant when adjusting for potential confounding sociodemographic, perinatal, and other dietary factors.
Conclusions: In this study assessing total food consumption of the mother during pregnancy, only few among the 27 food groups tested were weakly related to the development of advanced β‐cell autoimmunity in Finnish children.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21352426</pmid><doi>10.1111/j.1399-5448.2010.00668.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies autoantibodies Autoantibodies - analysis Autoantibodies - blood Autoimmunity Autoimmunity - physiology Beta cells Butter Children Coffee Diabetes mellitus Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - etiology Diabetes Mellitus, Type 1 - immunology Diets Disease Progression Eating - physiology epidemiology Female food Food consumption Fruit Fruits Glutamic acid Histocompatibility antigen HLA Humans Infant, Newborn Infants Insulin Insulin-Secreting Cells - immunology Inventories Islet cells Islets of Langerhans Margarine Maternal Nutritional Physiological Phenomena Nutrition Surveys Pregnancy Prenatal Exposure Delayed Effects - blood Prenatal Exposure Delayed Effects - epidemiology Prenatal Exposure Delayed Effects - immunology Progeny Risk Factors Risk groups type 1 |
| title | Maternal food consumption during pregnancy and risk of advanced β-cell autoimmunity in the offspring |
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