Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules

Complexes of specific assembly factors and generic endoplasmic reticulum (ER) chaperones, collectively called the MHC class I peptide-loading complex (PLC), function in the folding and assembly of MHC class I molecules. The glycan-binding chaperone calreticulin (CRT) and partner oxidoreductase ERp57...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-02, Vol.186 (4), p.2309-2320
Hauptverfasser:	Rizvi, Syed Monem, Del Cid, Natasha, Lybarger, Lonnie, Raghavan, Malini
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution - genetics Amino Acid Substitution - immunology Animals beta 2-Microglobulin - deficiency beta 2-Microglobulin - genetics Cell Line Cell Line, Tumor Conserved Sequence - immunology HLA-A2 Antigen - genetics HLA-A2 Antigen - metabolism HLA-A2 Antigen - physiology Humans Membrane Transport Proteins - chemistry Membrane Transport Proteins - metabolism Membrane Transport Proteins - physiology Mice Mice, Inbred C57BL Mice, Knockout Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Polysaccharides - chemistry Polysaccharides - metabolism Polysaccharides - physiology Protein Folding Signal Transduction - genetics Signal Transduction - immunology
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