P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses

G protein-coupled receptor (GPCR) activation elicits neutrophil responses such as chemotaxis and reactive oxygen species (ROS) formation, which depend on the small G protein Rac and are essential for host defense. P-Rex and Vav are two families of guanine-nucleotide exchange factors (GEFs) for Rac,...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-02, Vol.186 (3), p.1467-1476
Hauptverfasser:	Lawson, Campbell D, Donald, Sarah, Anderson, Karen E, Patton, Daniel T, Welch, Heidi C E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion - immunology Cell Line Chemotaxis, Leukocyte - immunology Guanine Nucleotide Exchange Factors - deficiency Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - physiology Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neuropeptides - biosynthesis Neutrophil Activation - immunology Neutrophils - immunology Neutrophils - metabolism Proto-Oncogene Proteins c-vav - deficiency Proto-Oncogene Proteins c-vav - genetics Proto-Oncogene Proteins c-vav - physiology rac GTP-Binding Proteins - biosynthesis rac1 GTP-Binding Protein RAC2 GTP-Binding Protein Reactive Oxygen Species - metabolism Receptors, G-Protein-Coupled - physiology
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