Risk of Non-melanoma Skin Cancer in Autoimmune Hepatitis
Background Most patients with autoimmune hepatitis (AIH) require long-term immunosuppressive therapy (IS). While it is well established that solid organ transplant recipients have a high risk of developing non-melanoma skin cancer (NMSC) as a result of immunosuppression, little is known about the ri...
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| Veröffentlicht in: | Digestive diseases and sciences 2010-11, Vol.55 (11), p.3218-3223 |
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| creator | Leung, John Dowling, Lauren Obadan, Isi Davis, James Bonis, Peter A. Kaplan, Marshall M. Casey, Darlene Viveiros, Kathleen |
| description | Background
Most patients with autoimmune hepatitis (AIH) require long-term immunosuppressive therapy (IS). While it is well established that solid organ transplant recipients have a high risk of developing non-melanoma skin cancer (NMSC) as a result of immunosuppression, little is known about the risk of NMSC associated with IS in patients with AIH.
Objectives
The aim of this study is to determine the incidence and risk factors for NMSC in patients on IS for AIH.
Methods
We reviewed the medical records of all patients with AIH seen at a tertiary care medical center between 1998 and 2008. We compared the incidence of NMSC to an age- and sex-matched control population and analyzed risk factors for NMSC.
Results
A total of forty-five patients with AIH were identified. Twenty NMSC lesions were found in eight patients. Compared to the age and sex-matched general population, the risk of SCC and BCC were increased as quantified by elevated standardized incidence ratios (28.5 and 5.0, respectively). Patients who developed NMSC were on average 24 years older (78.4 vs. 54.2 years old,
p
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| doi_str_mv | 10.1007/s10620-010-1145-1 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_907149962</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712949308</galeid><sourcerecordid>A712949308</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-3f37ab760c49ee5cb237b49ca5a26b3c8fa542f048f8b203a4a072dd073dc6293</originalsourceid><addsrcrecordid>eNqFkUtv1DAQxy0EokvhA3BBEQhxShm_4-NqBbRS1Uo8zpbj2JXbxF7s5MC3x6ssVKAi5INnPL95-Y_QSwxnGEC-LxgEgRYwtBgz3uJHaIO5pC3honuMNoBFtTEWJ-hZKbcAoCQWT9EJqRGupNyg7nMod03yzVWK7eRGE9Nkmi93ITY7E63LTbW2y5zCNC3RNedub-Ywh_IcPfFmLO7F8T5F3z5--Lo7by-vP13stpetZUrNLfVUml4KqK5z3PaEyp4pa7ghoqe284Yz4oF1vusJUMMMSDIMIOlgBVH0FL1b6-5z-r64MuspFOvGOqlLS9EKJK6dBPkvKbnqJKPAKvn6L_I2LTnWNXRXfxQrTroKvVmhGzM6HaJPczb2UFJvJSaKKQoH6uwBqp7BTcGm6Hyo738k4DXB5lRKdl7vc5hM_qEx6IOqelVVw8Gvqmpcc14d5136yQ2_M37JWIG3R8AUa0afq3Sh3HOUEVAKKkdWrtRQvHH5fvF_d_8JlDq1DA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>806219528</pqid></control><display><type>article</type><title>Risk of Non-melanoma Skin Cancer in Autoimmune Hepatitis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Leung, John ; Dowling, Lauren ; Obadan, Isi ; Davis, James ; Bonis, Peter A. ; Kaplan, Marshall M. ; Casey, Darlene ; Viveiros, Kathleen</creator><creatorcontrib>Leung, John ; Dowling, Lauren ; Obadan, Isi ; Davis, James ; Bonis, Peter A. ; Kaplan, Marshall M. ; Casey, Darlene ; Viveiros, Kathleen</creatorcontrib><description>Background
Most patients with autoimmune hepatitis (AIH) require long-term immunosuppressive therapy (IS). While it is well established that solid organ transplant recipients have a high risk of developing non-melanoma skin cancer (NMSC) as a result of immunosuppression, little is known about the risk of NMSC associated with IS in patients with AIH.
Objectives
The aim of this study is to determine the incidence and risk factors for NMSC in patients on IS for AIH.
Methods
We reviewed the medical records of all patients with AIH seen at a tertiary care medical center between 1998 and 2008. We compared the incidence of NMSC to an age- and sex-matched control population and analyzed risk factors for NMSC.
Results
A total of forty-five patients with AIH were identified. Twenty NMSC lesions were found in eight patients. Compared to the age and sex-matched general population, the risk of SCC and BCC were increased as quantified by elevated standardized incidence ratios (28.5 and 5.0, respectively). Patients who developed NMSC were on average 24 years older (78.4 vs. 54.2 years old,
p
< 0.0001) and had AIH diagnosed at a more advanced age (66.0 vs. 45.4 years old,
p
= 0.0003).
Conclusion
The risk of NMSC is significantly increased in patients with AIH on immunosuppression. Independent risk factors include current age and age at diagnosis of AIH.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-010-1145-1</identifier><identifier>PMID: 20165977</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biochemistry ; Biological and medical sciences ; Care and treatment ; Chronic active hepatitis ; Comorbidity ; Comparative analysis ; Dermatology ; Development and progression ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis, Autoimmune - drug therapy ; Hepatitis, Autoimmune - epidemiology ; Hepatology ; Humans ; Immunocompromised Host ; Immunotherapy ; Incidence ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Logistic Models ; Male ; Medical centers ; Medical records ; Medical research ; Medical sciences ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Melanoma ; Melanoma - epidemiology ; Middle Aged ; Multivariate Analysis ; Oncology ; Organ transplant recipients ; Original Article ; Other diseases. Semiology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Skin cancer ; Skin Neoplasms - epidemiology ; Transplant Surgery ; Transplantation of organs, tissues, etc ; Tumors of the skin and soft tissue. Premalignant lesions ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Young Adult</subject><ispartof>Digestive diseases and sciences, 2010-11, Vol.55 (11), p.3218-3223</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-3f37ab760c49ee5cb237b49ca5a26b3c8fa542f048f8b203a4a072dd073dc6293</citedby><cites>FETCH-LOGICAL-c499t-3f37ab760c49ee5cb237b49ca5a26b3c8fa542f048f8b203a4a072dd073dc6293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-010-1145-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-010-1145-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23420990$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20165977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leung, John</creatorcontrib><creatorcontrib>Dowling, Lauren</creatorcontrib><creatorcontrib>Obadan, Isi</creatorcontrib><creatorcontrib>Davis, James</creatorcontrib><creatorcontrib>Bonis, Peter A.</creatorcontrib><creatorcontrib>Kaplan, Marshall M.</creatorcontrib><creatorcontrib>Casey, Darlene</creatorcontrib><creatorcontrib>Viveiros, Kathleen</creatorcontrib><title>Risk of Non-melanoma Skin Cancer in Autoimmune Hepatitis</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background
Most patients with autoimmune hepatitis (AIH) require long-term immunosuppressive therapy (IS). While it is well established that solid organ transplant recipients have a high risk of developing non-melanoma skin cancer (NMSC) as a result of immunosuppression, little is known about the risk of NMSC associated with IS in patients with AIH.
Objectives
The aim of this study is to determine the incidence and risk factors for NMSC in patients on IS for AIH.
Methods
We reviewed the medical records of all patients with AIH seen at a tertiary care medical center between 1998 and 2008. We compared the incidence of NMSC to an age- and sex-matched control population and analyzed risk factors for NMSC.
Results
A total of forty-five patients with AIH were identified. Twenty NMSC lesions were found in eight patients. Compared to the age and sex-matched general population, the risk of SCC and BCC were increased as quantified by elevated standardized incidence ratios (28.5 and 5.0, respectively). Patients who developed NMSC were on average 24 years older (78.4 vs. 54.2 years old,
p
< 0.0001) and had AIH diagnosed at a more advanced age (66.0 vs. 45.4 years old,
p
= 0.0003).
Conclusion
The risk of NMSC is significantly increased in patients with AIH on immunosuppression. Independent risk factors include current age and age at diagnosis of AIH.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Care and treatment</subject><subject>Chronic active hepatitis</subject><subject>Comorbidity</subject><subject>Comparative analysis</subject><subject>Dermatology</subject><subject>Development and progression</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis, Autoimmune - drug therapy</subject><subject>Hepatitis, Autoimmune - epidemiology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Immunotherapy</subject><subject>Incidence</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical centers</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Melanoma</subject><subject>Melanoma - epidemiology</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Oncology</subject><subject>Organ transplant recipients</subject><subject>Original Article</subject><subject>Other diseases. Semiology</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Transplant Surgery</subject><subject>Transplantation of organs, tissues, etc</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Young Adult</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtv1DAQxy0EokvhA3BBEQhxShm_4-NqBbRS1Uo8zpbj2JXbxF7s5MC3x6ssVKAi5INnPL95-Y_QSwxnGEC-LxgEgRYwtBgz3uJHaIO5pC3honuMNoBFtTEWJ-hZKbcAoCQWT9EJqRGupNyg7nMod03yzVWK7eRGE9Nkmi93ITY7E63LTbW2y5zCNC3RNedub-Ywh_IcPfFmLO7F8T5F3z5--Lo7by-vP13stpetZUrNLfVUml4KqK5z3PaEyp4pa7ghoqe284Yz4oF1vusJUMMMSDIMIOlgBVH0FL1b6-5z-r64MuspFOvGOqlLS9EKJK6dBPkvKbnqJKPAKvn6L_I2LTnWNXRXfxQrTroKvVmhGzM6HaJPczb2UFJvJSaKKQoH6uwBqp7BTcGm6Hyo738k4DXB5lRKdl7vc5hM_qEx6IOqelVVw8Gvqmpcc14d5136yQ2_M37JWIG3R8AUa0afq3Sh3HOUEVAKKkdWrtRQvHH5fvF_d_8JlDq1DA</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Leung, John</creator><creator>Dowling, Lauren</creator><creator>Obadan, Isi</creator><creator>Davis, James</creator><creator>Bonis, Peter A.</creator><creator>Kaplan, Marshall M.</creator><creator>Casey, Darlene</creator><creator>Viveiros, Kathleen</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20101101</creationdate><title>Risk of Non-melanoma Skin Cancer in Autoimmune Hepatitis</title><author>Leung, John ; Dowling, Lauren ; Obadan, Isi ; Davis, James ; Bonis, Peter A. ; Kaplan, Marshall M. ; Casey, Darlene ; Viveiros, Kathleen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-3f37ab760c49ee5cb237b49ca5a26b3c8fa542f048f8b203a4a072dd073dc6293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Care and treatment</topic><topic>Chronic active hepatitis</topic><topic>Comorbidity</topic><topic>Comparative analysis</topic><topic>Dermatology</topic><topic>Development and progression</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatitis, Autoimmune - drug therapy</topic><topic>Hepatitis, Autoimmune - epidemiology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Immunotherapy</topic><topic>Incidence</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical centers</topic><topic>Medical records</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Melanoma</topic><topic>Melanoma - epidemiology</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Oncology</topic><topic>Organ transplant recipients</topic><topic>Original Article</topic><topic>Other diseases. Semiology</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Skin cancer</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Transplant Surgery</topic><topic>Transplantation of organs, tissues, etc</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leung, John</creatorcontrib><creatorcontrib>Dowling, Lauren</creatorcontrib><creatorcontrib>Obadan, Isi</creatorcontrib><creatorcontrib>Davis, James</creatorcontrib><creatorcontrib>Bonis, Peter A.</creatorcontrib><creatorcontrib>Kaplan, Marshall M.</creatorcontrib><creatorcontrib>Casey, Darlene</creatorcontrib><creatorcontrib>Viveiros, Kathleen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leung, John</au><au>Dowling, Lauren</au><au>Obadan, Isi</au><au>Davis, James</au><au>Bonis, Peter A.</au><au>Kaplan, Marshall M.</au><au>Casey, Darlene</au><au>Viveiros, Kathleen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of Non-melanoma Skin Cancer in Autoimmune Hepatitis</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>55</volume><issue>11</issue><spage>3218</spage><epage>3223</epage><pages>3218-3223</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Background
Most patients with autoimmune hepatitis (AIH) require long-term immunosuppressive therapy (IS). While it is well established that solid organ transplant recipients have a high risk of developing non-melanoma skin cancer (NMSC) as a result of immunosuppression, little is known about the risk of NMSC associated with IS in patients with AIH.
Objectives
The aim of this study is to determine the incidence and risk factors for NMSC in patients on IS for AIH.
Methods
We reviewed the medical records of all patients with AIH seen at a tertiary care medical center between 1998 and 2008. We compared the incidence of NMSC to an age- and sex-matched control population and analyzed risk factors for NMSC.
Results
A total of forty-five patients with AIH were identified. Twenty NMSC lesions were found in eight patients. Compared to the age and sex-matched general population, the risk of SCC and BCC were increased as quantified by elevated standardized incidence ratios (28.5 and 5.0, respectively). Patients who developed NMSC were on average 24 years older (78.4 vs. 54.2 years old,
p
< 0.0001) and had AIH diagnosed at a more advanced age (66.0 vs. 45.4 years old,
p
= 0.0003).
Conclusion
The risk of NMSC is significantly increased in patients with AIH on immunosuppression. Independent risk factors include current age and age at diagnosis of AIH.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>20165977</pmid><doi>10.1007/s10620-010-1145-1</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2010-11, Vol.55 (11), p.3218-3223 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_907149962 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Aged, 80 and over Biochemistry Biological and medical sciences Care and treatment Chronic active hepatitis Comorbidity Comparative analysis Dermatology Development and progression Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Hepatitis, Autoimmune - drug therapy Hepatitis, Autoimmune - epidemiology Hepatology Humans Immunocompromised Host Immunotherapy Incidence Liver. Biliary tract. Portal circulation. Exocrine pancreas Logistic Models Male Medical centers Medical records Medical research Medical sciences Medicine Medicine & Public Health Medicine, Experimental Melanoma Melanoma - epidemiology Middle Aged Multivariate Analysis Oncology Organ transplant recipients Original Article Other diseases. Semiology Retrospective Studies Risk Assessment Risk Factors Skin cancer Skin Neoplasms - epidemiology Transplant Surgery Transplantation of organs, tissues, etc Tumors of the skin and soft tissue. Premalignant lesions Vertebrates: anatomy and physiology, studies on body, several organs or systems Young Adult |
| title | Risk of Non-melanoma Skin Cancer in Autoimmune Hepatitis |
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