Heat Shock Protein 27 Differentiates Tolerogenic Macrophages That May Support Human Breast Cancer Progression

Tumor cells release several factors that can help the progression of the tumor by directly supporting tumor growth and/or suppressing host antitumor immunity. Here, we report that human primary breast tumor cells not only express elevated levels of heat shock protein 27 (Hsp27) at the intracellular...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2011-01, Vol.71 (2), p.318-327
Hauptverfasser:	BANERJEE, Sanjib, LIN, Chuen-Fu L, LANGSTEIN, Howard N, MILLER-GRAZIANO, Carol L, STRICKLAND, Jennifer, O'DONOGHUE, Lauren, DE, Asit K, SKINNER, Kristin A, SCHIFFHAUER, Linda M, PEACOCK, James, HICKS, David G, REDMOND, Eileen M, MORROW, David, HUSTON, Alissa, SHAYNE, Michelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Breast Neoplasms - blood Breast Neoplasms - blood supply Breast Neoplasms - immunology Breast Neoplasms - pathology Case-Control Studies Cell Differentiation - immunology Cell Line, Tumor Disease Progression Female Gynecology. Andrology. Obstetrics HSP27 Heat-Shock Proteins - blood HSP27 Heat-Shock Proteins - immunology HSP27 Heat-Shock Proteins - metabolism Humans Immune Tolerance Macrophages - immunology Macrophages - pathology Mammary gland diseases Medical sciences Monocytes - immunology Monocytes - pathology Neovascularization, Pathologic - immunology Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Pharmacology. Drug treatments T-Lymphocytes - immunology Tumor Microenvironment - immunology Tumors
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