RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity

The molecular mechanisms regulating self-renewal of leukemia stem cells remain poorly understood. Here we report the generation of 2 closely related leukemias created through the retroviral overexpression of Meis1 and Hoxa9. Despite their apparent common origin, these clonal leukemias exhibit enormo...

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Veröffentlicht in:	Blood 2011-01, Vol.117 (2), p.e27-e38
Hauptverfasser:	Wilhelm, Brian T., Briau, Mathieu, Austin, Pamela, Faubert, Amélie, Boucher, Geneviève, Chagnon, Pierre, Hope, Kristin, Girard, Simon, Mayotte, Nadine, Landry, Josette-Renee, Hébert, Josée, Sauvageau, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Clone Cells Flow Cytometry Gene Expression Profiling Gene Expression Regulation, Leukemic Genetic Vectors Homeodomain Proteins - genetics Leukemia, Myeloid, Acute - genetics Mice Mice, Inbred C57BL Microarray Analysis Myeloid Ecotropic Viral Integration Site 1 Protein Neoplasm Proteins - genetics Neoplastic Stem Cells Retroviridae Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, RNA
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