The challenge of new drug discovery for tuberculosis

Sustaining the fight against TB Although vaccination has been successful in some countries, tuberculosis (TB) is more prevalent in the world today than ever before, with nearly 10 million new cases expected yearly. Anil Koul and colleagues report on the various new TB drugs and treatment regimens un...

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Veröffentlicht in:	Nature (London) 2011-01, Vol.469 (7331), p.483-490
Hauptverfasser:	Koul, Anil, Arnoult, Eric, Lounis, Nacer, Guillemont, Jerome, Andries, Koen
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/309/2144 692/699/255/1856 Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular agents Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Bacterial infections Biological and medical sciences Cell Respiration - drug effects Clinical Trials as Topic Discovery and exploration Dosage and administration Drug Discovery Drug resistance Drug Resistance, Bacterial Drug Resistance, Multiple Drug targeting Drug therapy Host-Pathogen Interactions - drug effects Humanities and Social Sciences Humans Medical sciences Mortality multidisciplinary Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Pathogens Pharmaceutical industry Pharmacology. Drug treatments review-article Science Science (multidisciplinary) Signal Transduction - drug effects Tuberculosis Tuberculosis - drug therapy
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