Effects of Antioxidants of Different Nature on Functions of Tissue—Blood Barriers of the Neuroendocrine Center of Wistar White Rats of Both Sexes

Effects of natural (α-tocopherol) and synthetic (ionol) antioxidants on permeability of tissue--blood barriers of the hypothalamus-pituitary system to an alien (the dye neutral red) and physiologically adequate agent (^sup 3^H-thymidine) were studied in male and female Wistar rats. The antioxidants were established to enhance the protective function of the tissue--blood barriers, especially in females. The permeability to ^sup 3^H-thymidine in hypothalamus decreased only in males and only after effect of α-tocopherol, whereas in pituitary, in animals of both sexes and especially after action of the bioantioxidant.[PUBLICATION ABSTRACT]